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Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.
Carrillo, Robert A; Özkan, Engin; Menon, Kaushiki P; Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Jeon, Mili; Birnbaum, Michael E; Bellen, Hugo J; Garcia, K Christopher; Zinn, Kai.
Afiliación
  • Carrillo RA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA.
  • Özkan E; Dept. of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL.
  • Menon KP; Howard Hughes Medical Institute, Depts. of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.
  • Nagarkar-Jaiswal S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA.
  • Lee PT; Howard Hughes Medical Institute, Program in Developmental Biology, Dept. of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at TCH, Baylor College of Medicine, Houston, TX.
  • Jeon M; Howard Hughes Medical Institute, Program in Developmental Biology, Dept. of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at TCH, Baylor College of Medicine, Houston, TX.
  • Birnbaum ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA.
  • Bellen HJ; Howard Hughes Medical Institute, Depts. of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.
  • Garcia KC; Howard Hughes Medical Institute, Depts. of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA.
  • Zinn K; Howard Hughes Medical Institute, Program in Developmental Biology, Dept. of Molecular and Human Genetics, Jan and Dan Duncan Neurological Research Institute at TCH, Baylor College of Medicine, Houston, TX.
Cell ; 163(7): 1770-1782, 2015 Dec 17.
Article en En | MEDLINE | ID: mdl-26687361
We have defined a network of interacting Drosophila cell surface proteins in which a 21-member IgSF subfamily, the Dprs, binds to a nine-member subfamily, the DIPs. The structural basis of the Dpr-DIP interaction code appears to be dictated by shape complementarity within the Dpr-DIP binding interface. Each of the six dpr and DIP genes examined here is expressed by a unique subset of larval and pupal neurons. In the neuromuscular system, interactions between Dpr11 and DIP-γ affect presynaptic terminal development, trophic factor responses, and neurotransmission. In the visual system, dpr11 is selectively expressed by R7 photoreceptors that use Rh4 opsin (yR7s). Their primary synaptic targets, Dm8 amacrine neurons, express DIP-γ. In dpr11 or DIP-γ mutants, yR7 terminals extend beyond their normal termination zones in layer M6 of the medulla. DIP-γ is also required for Dm8 survival or differentiation. Our findings suggest that Dpr-DIP interactions are important determinants of synaptic connectivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Inmunoglobulinas / Proteínas de Drosophila / Drosophila / Proteínas de la Membrana / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Inmunoglobulinas / Proteínas de Drosophila / Drosophila / Proteínas de la Membrana / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos