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Indicators of iron status are correlated with adiponectin expression in adipose tissue of patients with morbid obesity.
Pihan-Le Bars, F; Bonnet, F; Loréal, O; Le Loupp, A-G; Ropert, M; Letessier, E; Prieur, X; Bach, K; Deugnier, Y; Fromenty, B; Cariou, B.
Afiliación
  • Pihan-Le Bars F; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France; Service d'Endocrinologie-Diabétologie, CHU de Rennes, 35200 Rennes, France.
  • Bonnet F; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France; Service d'Endocrinologie-Diabétologie, CHU de Rennes, 35200 Rennes, France. Electronic address: fabrice.bonnet@chu-rennes.fr.
  • Loréal O; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France; Centre National de Référence des surcharges en fer rares d'origine génétique, CHU Pontchaillou, 35000 Rennes, France.
  • Le Loupp AG; Laboratoire de Biochimie, CHU de Nantes, 44000 Nantes, France; Université de Nantes, 44000 Nantes, France.
  • Ropert M; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France; Laboratoire de Biochimie, CHU de Rennes, 35000 Rennes, France.
  • Letessier E; Clinique de Chirurgie Digestive et Endocrinienne, CHU de Nantes, 44000 Nantes, France.
  • Prieur X; Université de Nantes, 44000 Nantes, France; Inserm, UMR 1087-CNRS UMR 6291, l'Institut du Thorax, 44000 Nantes, France.
  • Bach K; Laboratoire de Biochimie, CHU de Nantes, 44000 Nantes, France; Université de Nantes, 44000 Nantes, France.
  • Deugnier Y; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France; Centre National de Référence des surcharges en fer rares d'origine génétique, CHU Pontchaillou, 35000 Rennes, France; Service des maladies du foie, CHU de Rennes, 35000 Rennes, France.
  • Fromenty B; Inserm, UMR 991, Université de Rennes 1, 35000 Rennes, France.
  • Cariou B; Université de Nantes, 44000 Nantes, France; Inserm, UMR 1087-CNRS UMR 6291, l'Institut du Thorax, 44000 Nantes, France; CHU de Nantes, clinique d'Endocrinologie, l'Institut du Thorax, 44000 Nantes, France.
Diabetes Metab ; 42(2): 105-11, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26677772
AIM: The aim of this study was to assess interactions between glucose and iron homoeostasis in the adipose tissue (AT) of obese subjects. METHODS: A total of 46 obese patients eligible for bariatric surgery were recruited into the study. Anthropometric and biochemical characteristics were assessed, and biopsies of subcutaneous (SCAT) and visceral adipose tissue (VAT) performed. The mRNA levels of genes involved in iron and glucose homoeostasis were measured in their AT and compared with a pool of control samples. RESULTS: Gene expression of hepcidin (HAMP) was significantly increased in the SCAT and VAT of obese patients, while transferrin receptor (TFRC) expression was reduced, compared with non-obese controls, suggesting a higher iron load in obese patients. Also, mRNA levels of adiponectin (ADIPOQ) were decreased in both SCAT and VAT in obese patients, and correlated negatively with hepcidin expression, while adiponectin expression was positively correlated with TFRC expression in both SCAT and VAT. Interestingly, TFRC expression in VAT correlated negatively with several metabolic parameters, such as fasting blood glucose and LDL cholesterol. CONCLUSION: Iron content appears to be increased in the SCAT and VAT of obese patients, and negatively correlated with adiponectin expression, which could be contributing to insulin resistance and the metabolic complications of obesity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Tejido Adiposo / Adiponectina / Hierro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Tejido Adiposo / Adiponectina / Hierro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Diabetes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Francia