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Role of Second Transplantation for Children With Acute Myeloid Leukemia Following Posttransplantation Relapse.
Taga, Takashi; Murakami, Yoshitaka; Tabuchi, Ken; Adachi, Souichi; Tomizawa, Daisuke; Kojima, Yasuko; Kato, Koji; Koike, Kazutoshi; Koh, Katsuyoshi; Kajiwara, Ryosuke; Hamamoto, Kazuko; Yabe, Hiromasa; Kawa, Keisei; Atsuta, Yoshiko; Kudo, Kazuko.
Afiliación
  • Taga T; Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
  • Murakami Y; Department of Medical Statistics, Toho University, Tokyo, Japan.
  • Tabuchi K; Division of Pediatrics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  • Adachi S; Department of Human Health Science, Kyoto University, Kyoto, Japan.
  • Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Kojima Y; Department of Pediatrics, Toho University Omori Hospital, Tokyo, Japan.
  • Kato K; Department of Pediatric Hematology/Oncology, Nagoya First Red Cross Hospital, Nagoya, Japan.
  • Koike K; Department of Hematology/Oncology, Ibaraki Children's Hospital, Mito, Japan.
  • Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
  • Kajiwara R; Department of Pediatrics, Yokohama City University, Yokohama, Japan.
  • Hamamoto K; Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan.
  • Yabe H; Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan.
  • Kawa K; Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan.
  • Atsuta Y; Department of Healthcare Administration, Nagoya University, Nagoya, Japan.
  • Kudo K; Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya University, Nagoya, Japan.
Pediatr Blood Cancer ; 63(4): 701-5, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26670954
BACKGROUND: In children with acute myeloid leukemia (AML), hematopoietic stem cell transplantation (HSCT) in first remission is indicated for patients with a relatively high risk of relapse. Second HSCT is a curative option; however, few reports have been published about a second HSCT in children for AML with posttransplantation relapse. PROCEDURE: Using the database provided by the Japanese Society of Hematopoietic Cell Transplantation, we analyzed 46 children with AML who underwent a second allogeneic HSCT after achieving a second remission. RESULTS: The median duration from the first to second HSCT was 20 months, and the source of the second HSCT was related bone marrow (BM) in 22, related peripheral blood in 6, unrelated BM in 14, and unrelated cord blood in 4 patients. Twenty-five children eventually died of the following causes: progressive disease in 14 and transplant-related toxicities in 9. The 5-year overall survival rate was 41.7 ± 7.7%. An interval of less than 24 months between the first and second HSCT was a significant poor prognostic factor. CONCLUSIONS: Children with AML who experience a relapse after HSCT in first remission have a good chance of survival with a second HSCT if a second remission is achieved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Recurrencia Local de Neoplasia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Blood Cancer Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos