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Predictive factors of pathological vascular invasion in hepatocellular carcinoma within 3 cm and three nodules without radiological vascular invasion.
Masuda, Toshiro; Beppu, Toru; Okabe, Hirohisa; Nitta, Hidetoshi; Imai, Katsunori; Hayashi, Hiromitsu; Chikamoto, Akira; Yamamoto, Kenichiro; Ikeshima, Satoshi; Kuramoto, Masafumi; Shimada, Shinya; Baba, Hideo.
Afiliación
  • Masuda T; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Beppu T; Department of Surgery, Kumamoto General Hospital, Japan Community Health Care Organization, Kumamoto, Japan.
  • Okabe H; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Nitta H; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Imai K; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Hayashi H; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Chikamoto A; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Yamamoto K; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.
  • Ikeshima S; Department of Surgery, Kumamoto General Hospital, Japan Community Health Care Organization, Kumamoto, Japan.
  • Kuramoto M; Department of Surgery, Kumamoto General Hospital, Japan Community Health Care Organization, Kumamoto, Japan.
  • Shimada S; Department of Surgery, Kumamoto General Hospital, Japan Community Health Care Organization, Kumamoto, Japan.
  • Baba H; Department of Surgery, Kumamoto General Hospital, Japan Community Health Care Organization, Kumamoto, Japan.
Hepatol Res ; 46(10): 985-91, 2016 Sep.
Article en En | MEDLINE | ID: mdl-26670198
AIM: The aim of this study was to determine the predictive factors of pathological vascular invasion as contra-indicators for ablation therapy in patients with hepatocellular carcinoma (HCC) within 3 cm and three nodules without radiological vascular invasion. METHODS: Two hundred and seventeen patients with HCC within 3 cm and three nodules without radiological vascular invasion who underwent hepatic resection were retrospectively investigated. RESULTS: Pathological vascular invasion was positive in 46 patients, consisting of 38 portal vein invasions, three hepatic vein invasions, two hepatic artery invasions, one hepatic duct invasion and two with portal and hepatic vein invasions. In univariate analysis, patients with α-fetoprotein (AFP) of more than 100 ng/mL had higher rates of pathological vascular invasion than those without. In addition, patients with protein induced by vitamin K absence (PIVKA-II) of more than 100 mAU/mL had higher rates of pathological vascular invasion than those without. Multivariate analysis revealed that AFP of more than 100 ng/mL and PIVKA-II of more than 100 mAU/mL were independent predictive factors for pathological vascular invasion. As these patients were treated with hepatic resection, cumulative 5-year recurrence-free and overall survivals were not significantly different between the pathological vascular invasion negative and positive cases. CONCLUSION: AFP of more than 100 ng/mL and PIVKA-II of more than 100 mAU/mL can predict pathological vascular invasion in patients with HCC within 3 cm and three nodules without radiological vascular invasion. In treating such cases, hepatic resection rather than local ablation therapy is recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos