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Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
Wang, Qiang; Li, Miaoxin; Yang, Zhenxing; Hu, Xun; Wu, Hei-Man; Ni, Peiyan; Ren, Hongyan; Deng, Wei; Li, Mingli; Ma, Xiaohong; Guo, Wanjun; Zhao, Liansheng; Wang, Yingcheng; Xiang, Bo; Lei, Wei; Sham, Pak C; Li, Tao.
Afiliación
  • Wang Q; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Li M; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Yang Z; State Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic Sciences and Department of Psychiatry, University of Hong Kong, Pokfulam, S.A.R. China.
  • Hu X; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Wu HM; State Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic Sciences and Department of Psychiatry, University of Hong Kong, Pokfulam, S.A.R. China.
  • Ni P; Biobank, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Ren H; State Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic Sciences and Department of Psychiatry, University of Hong Kong, Pokfulam, S.A.R. China.
  • Deng W; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Li M; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Ma X; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Guo W; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Zhao L; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Wang Y; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Xiang B; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Lei W; State Key Laboratory of Biotherapy, Psychiatric laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Sham PC; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
  • Li T; Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P R China.
Sci Rep ; 5: 18209, 2015 Dec 15.
Article en En | MEDLINE | ID: mdl-26666178
Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of schizophrenia. We performed exome sequencing in Chinese patients (N = 45) with schizophrenia and their unaffected parents (N = 90). Forty genes were found to contain DNVs. These genes had enriched transcriptional co-expression profile in prenatal frontal cortex (Bonferroni corrected p < 9.1 × 10(-3)), and in prenatal temporal and parietal regions (Bonferroni corrected p < 0.03). Also, four prenatal anatomical subregions (VCF, MFC, OFC and ITC) have shown significant enrichment of connectedness in co-expression networks. Moreover, four genes (LRP1, MACF1, DICER1 and ABCA2) harboring the damaging de novo mutations are strongly prioritized as susceptibility genes by multiple evidences. Our findings in Chinese schizophrenic patients indicate the pathogenic role of DNVs, supporting the hypothesis that schizophrenia is a neurodevelopmental disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Expresión Génica / Predisposición Genética a la Enfermedad / Pueblo Asiatico / Desarrollo Embrionario / Estudios de Asociación Genética / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Expresión Génica / Predisposición Genética a la Enfermedad / Pueblo Asiatico / Desarrollo Embrionario / Estudios de Asociación Genética / Mutación Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido