Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms.

Terpolilli, Nicole A; Feiler, Sergej; Dienel, Ari; Müller, Frank; Heumos, Nicole; Friedrich, Benjamin; Stover, John; Thal, Serge; Schöller, Karsten; Plesnila, Nikolaus

Terpolilli, Nicole A; Feiler, Sergej; Dienel, Ari; Müller, Frank; Heumos, Nicole; Friedrich, Benjamin; Stover, John; Thal, Serge; Schöller, Karsten; Plesnila, Nikolaus.

Afiliación

Terpolilli NA; Department of Neurosurgery, University of Munich Medical Center, Munich, Germany.
Feiler S; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.
Dienel A; Institute for Stroke and Dementia Research, University of Munich Medical Center, Munich, Germany.
Müller F; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.
Heumos N; Department of Neurosurgery, University of Munich Medical Center, Munich, Germany.
Friedrich B; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.
Stover J; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.
Thal S; Department of Neurosurgery, University of Munich Medical Center, Munich, Germany.
Schöller K; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.
Plesnila N; Institute for Surgical Research, University of Munich Medical Center, Munich, Germany.

J Cereb Blood Flow Metab ; 36(12): 2096-2107, 2016 12.

Article en En | MEDLINE | ID: mdl-26661144

Asunto(s)

Microvasos/efectos de los fármacos; Óxido Nítrico/farmacología; Hemorragia Subaracnoidea/tratamiento farmacológico; Vasoespasmo Intracraneal/tratamiento farmacológico; Administración por Inhalación; Animales; Edema Encefálico/prevención & control; Lesiones Encefálicas/prevención & control; Hipocampo/patología; Ratones; Ratones Endogámicos C57BL; Microvasos/fisiopatología; Óxido Nítrico/administración & dosificación; Óxido Nítrico/uso terapéutico; Hemorragia Subaracnoidea/mortalidad; Hemorragia Subaracnoidea/patología; Resultado del Tratamiento; Vasoespasmo Intracraneal/prevención & control

Palabras clave

Cerebral perfusion; early brain injury; microvasospasm; nitric oxide; subarachnoid hemorrhage

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Subaracnoidea / Vasoespasmo Intracraneal / Microvasos / Óxido Nítrico Límite: Animals Idioma: En Revista: J Cereb Blood Flow Metab Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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