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Menses resumption after cancer treatment-induced amenorrhea occurs early or not at all.
Jacobson, Melanie H; Mertens, Ann C; Spencer, Jessica B; Manatunga, Amita K; Howards, Penelope P.
Afiliación
  • Jacobson MH; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. Electronic address: mhymanjacobson@emory.edu.
  • Mertens AC; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia.
  • Spencer JB; Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.
  • Manatunga AK; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
  • Howards PP; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Fertil Steril ; 105(3): 765-772.e4, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26658130
OBJECTIVE: To identify factors associated with cancer treatment-induced amenorrhea and time to return of menses. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): Female cancer survivors who were diagnosed with cancer between the ages of 20 and 35 and were at least 2 years postdiagnosis at the time of recruitment (median = 7 years; interquartile range, 5-11). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Amenorrhea (≥6 months without menses) and resumption of menses. RESULT(S): After excluding women with hysterectomies before cancer diagnosis, 1,043 women were eligible for analysis. Amenorrhea occurred in 31.6% of women. Among women treated with chemotherapy (n = 596), older age at diagnosis (30-35 vs. 20-24 years: adjusted odds ratio [aOR] = 2.37; 95% confidence interval [CI], 1.30, 4.30) and nulligravidity (vs. gravid: aOR = 1.50; 95% CI, 1.02, 2.21) were risk factors for amenorrhea. Among amenorrheic women, menses resumed in most (70.0%), and resumption occurred within 2 years of treatment for 90.0% of women. Survivors of breast cancer were more likely to resume menses at times greater than 1 year compared with lymphoma and pelvic-area cancers. Women diagnosed at older ages, those exposed to chemotherapy, and those exposed to any radiation experienced longer times to return of menses. Women who were older at diagnosis were more likely to have irregular cycles when menses returned. CONCLUSION(S): Treatment-induced amenorrhea is common in cancer survivors, although most women resume menses within 2 years. However, once resumed, older women are more likely to have irregular cycles. Age at diagnosis and pregnancy history affect the risk of amenorrhea.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Sobrevivientes / Amenorrea / Ciclo Menstrual / Neoplasias / Antineoplásicos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Fertil Steril Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Sobrevivientes / Amenorrea / Ciclo Menstrual / Neoplasias / Antineoplásicos Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Fertil Steril Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos