Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin.

Umeyor, Chukwuebuka; Attama, Anthony; Uronnachi, Emmanuel; Kenechukwu, Franklin; Nwakile, Calistus; Nzekwe, Ifeanyi; Okoye, Eric; Esimone, Charles

Umeyor, Chukwuebuka; Attama, Anthony; Uronnachi, Emmanuel; Kenechukwu, Franklin; Nwakile, Calistus; Nzekwe, Ifeanyi; Okoye, Eric; Esimone, Charles.

Afiliación

Umeyor C; Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria. Electronic address: ec.umeyor@unizik.edu.ng.
Attama A; Drug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria. Electronic address: anthony.attama@unn.edu.ng.
Uronnachi E; Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria.
Kenechukwu F; Drug Delivery and Nanomedicines Research Group, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.
Nwakile C; Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria.
Nzekwe I; Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria.
Okoye E; Nanomedicines and Drug Delivery Research Group, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria.
Esimone C; Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra, Nigeria.

Int J Pharm ; 497(1-2): 161-98, 2016 Jan 30.

Article en En | MEDLINE | ID: mdl-26657350

Asunto(s)

Química Farmacéutica/métodos; Emulsionantes/química; Emulsiones/química; Gentamicinas/química; Nanotecnología/métodos; Polietilenglicoles/química; Administración Oral; Cápsulas; Estabilidad de Medicamentos; Gentamicinas/administración & dosificación; Gentamicinas/farmacología; Pruebas de Sensibilidad Microbiana; Nanopartículas/química; Nanopartículas/ultraestructura; Tamaño de la Partícula; Permeabilidad; Transición de Fase/efectos de los fármacos; Solubilidad; Factores de Tiempo; Viscosidad

Palabras clave

Castor oil (PubChem CID: 14030006); Gentamicin; Gentamicin (PubChem CID: 3467); Kolliphor(®) EL (PubChem CID: 5849927); Kolliphor(®) P188 (PubChem CID: 24751); Maisine(®) 35-1 oil (PubChem CID: 6436630); PEG 4000; PEG 4000 (PubChem CID: 174); Polysorbate 80 (PubChem CID: 5284448); Propylene glycol (PubChem CID: 1030); Self-nanoemulsifying formulations; Surface modification; Ternary phase diagrams; Transcutol(®) HP (PubChem CID: 8146); Zeta potential; n-octanol (PubChem CID: 957)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Gentamicinas / Química Farmacéutica / Nanotecnología / Emulsionantes / Emulsiones Idioma: En Revista: Int J Pharm Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

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