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Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.
Mostaghaci, Babak; Loretz, Brigitta; Lehr, Claus-Michael.
Afiliación
  • Loretz B; Department of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI); Saarland University, Campus E8.1, 66123 Saarbrucken, Germany. Brigitta.Loretz@helmholtzhzi.de.
  • Lehr CM; Department of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI); Saarland University, Campus E8.1, 66123 Saarbrucken, Germany. Claus-Michael.Lehr@helmholtzhzi.de.
Curr Pharm Des ; 22(11): 1529-33, 2016.
Article en En | MEDLINE | ID: mdl-26654437
Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos de Calcio / Terapia Genética / Técnicas de Transferencia de Gen / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2016 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos
Buscar en Google
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Imprimir
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos de Calcio / Terapia Genética / Técnicas de Transferencia de Gen / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2016 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos