Your browser doesn't support javascript.
loading
Human colon cancer targeted pro-apoptotic, anti-metastatic and cytostatic effects of binuclear Silver(I)-N-Heterocyclic carbene (NHC) complexes.
Asif, Muhammad; Iqbal, Muhammad Adnan; Hussein, Mouayed A; Oon, Chern Ein; Haque, Rosenani A; Khadeer Ahamed, Mohamed B; Abdul Majid, Aman Shah; Abdul Majid, Amin Malik Shah.
Afiliación
  • Asif M; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
  • Iqbal MA; School of Chemical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia; Department of Chemistry, University of Agriculture, Faisalabad 38000, Pakistan; Community College, University of Agriculture, Faisalabad 38000, Pakistan.
  • Hussein MA; University of Basrah, College of Science, Department of Chemistry, Basra 61004, Iraq.
  • Oon CE; Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
  • Haque RA; School of Chemical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia. Electronic address: rosenani@usm.my.
  • Khadeer Ahamed MB; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia.
  • Abdul Majid AS; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang, 13200, Malaysia.
  • Abdul Majid AMS; EMAN Testing and Research Laboratory, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800-USM, Penang, Malaysia. Electronic address: aminmalikshah@usm.my.
Eur J Med Chem ; 108: 177-187, 2016 Jan 27.
Article en En | MEDLINE | ID: mdl-26649905
The current mechanistic study was conducted to explore the effects of increased lipophilicity of binuclear silver(I)-NHC complexes on cytotoxicity. Two new silver(I)-N-Heterocyclic Carbene (NHC) complexes (3 and 4), having lypophilic terminal alkyl chains (Octyl and Decyl), were derived from meta-xylyl linked bis-benzimidazolium salts (1 and 2). Each of the synthesized compounds was characterized by microanalysis and spectroscopic techniques. The complexes were tested for their cytotoxicity against a panel of human cancer c as well normal cell lines using MTT assay. Based on MTT assay results, complex 4 was found to be selectively toxic towards human colorectal carcinoma cell line (HCT 116). Complex 4 was further studied in detail to explore the mechanism of cell death and findings of the study revealed that complex 4 has promising pro-apoptotic and anti-metastatic activities against HCT 116 cells. Furthermore, it showed pronounced cytostatic effects in HCT 116 multicellular spheroid model. Hence, binuclear silver(I)-NHC complexes with longer terminal aliphatic chains have worth to be further studied against human colon cancer for the purpose of drug development.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias del Colon / Complejos de Coordinación / Compuestos Heterocíclicos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2016 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias del Colon / Complejos de Coordinación / Compuestos Heterocíclicos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2016 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Francia