Your browser doesn't support javascript.
loading
Clinical Dementia Rating Scale Detects White Matter Changes in Older Adults at Risk for Alzheimer's Disease.
Chang, Yu-Ling; Yen, Yu-Shiuan; Chen, Ta-Fu; Yan, Sui-Hing; Tseng, Wen-Yih Isaac.
Afiliación
  • Chang YL; Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan.
  • Yen YS; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan.
  • Chen TF; Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan.
  • Yan SH; Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Tseng WY; Section of Neurology, Renai Branch, Taipei City Hospital, Taipei, Taiwan.
J Alzheimers Dis ; 50(2): 411-23, 2016.
Article en En | MEDLINE | ID: mdl-26639963
This study investigated the putative changes in regional gray matter and cingulum bundle segments in mild cognitive impairment (MCI) by using two diagnostic criteria. Participants comprised 50 older adults with MCI and 22 healthy older controls (HC). The older adults with MCI were further divided into two groups defined by a global Clinical Dementia Rating (CDR) score of 0.5 and with (the CDR/NPT MCI group) or without (the CDR MCI group) objective cognitive impairments determined using neuropsychological tests (NPTs). Comparable regional gray matter integrity was observed among the three groups. However, the integrity of the right inferior segment of the cingulum bundle in the two MCI groups was more reduced than that in the HC group, and the CDR/NPT MCI group exhibited additional disruption in the left inferior cingulum bundle. The results also demonstrated that neuropsychological measures have greater predictive value for changes in white matter beyond the contribution of an informant-based instrument alone. Overall, the findings confirm the utility of informant-based assessment in detecting microstructural brain changes in high-risk older adults, even before objective cognitive impairment is evident. The findings also suggest that combining the neuropsychological measures with the informant-based assessment provided the greatest predictive value in assessing white matter disruption. The essential role of the white matter measurement as a biomarker for detecting individuals at a high risk of developing dementia was highlighted.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Trastornos del Conocimiento / Enfermedad de Alzheimer / Sustancia Blanca Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Trastornos del Conocimiento / Enfermedad de Alzheimer / Sustancia Blanca Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos