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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.
Woerner, Andreas C; Frottin, Frédéric; Hornburg, Daniel; Feng, Li R; Meissner, Felix; Patra, Maria; Tatzelt, Jörg; Mann, Matthias; Winklhofer, Konstanze F; Hartl, F Ulrich; Hipp, Mark S.
Afiliación
  • Woerner AC; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  • Frottin F; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  • Hornburg D; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  • Feng LR; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  • Meissner F; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
  • Patra M; Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany.
  • Tatzelt J; Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany. Department of Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.
  • Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany.
  • Winklhofer KF; Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany. Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany. Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochu
  • Hartl FU; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany. hipp@biochem.mpg.de uhartl@biochem.mpg.de.
  • Hipp MS; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany. hipp@biochem.mpg.de uhartl@biochem.mpg.de.
Science ; 351(6269): 173-6, 2016 Jan 08.
Article en En | MEDLINE | ID: mdl-26634439
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Núcleo Celular / Enfermedades Neurodegenerativas / Citoplasma / Proteínas de Unión al ADN / Agregado de Proteínas / Proteínas del Tejido Nervioso Límite: Humans Idioma: En Revista: Science Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Núcleo Celular / Enfermedades Neurodegenerativas / Citoplasma / Proteínas de Unión al ADN / Agregado de Proteínas / Proteínas del Tejido Nervioso Límite: Humans Idioma: En Revista: Science Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos