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Curcumin nanoparticles attenuate cardiac remodeling due to pulmonary arterial hypertension.
Rice, Kevin M; Manne, Nandini D P K; Kolli, Madhukar B; Wehner, Paulette S; Dornon, Lucy; Arvapalli, Ravikumar; Selvaraj, Vellaisamy; Kumar, Arun; Blough, Eric R.
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  • Rice KM; a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.
  • Manne ND; b School of Kinesiology , College of Health Professions, Marshall University , Huntington , WV , USA.
  • Kolli MB; c Biotechnology Department, West Virginia State University , Institute , WV , USA.
  • Wehner PS; d Department of Internal Medicine , Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
  • Dornon L; a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.
  • Arvapalli R; e Department of Public Health , College of Health Professions, Marshall University , Huntington , WV , USA.
  • Selvaraj V; a Center for Diagnostic Nanosystems , Marshall University , Huntington , WV , USA.
  • Kumar A; f Department of Pharmacology , Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
  • Blough ER; g Department of Cardiology , Joan C. Edwards School of Medicine, Marshall University , Huntington , WV , USA.
Artif Cells Nanomed Biotechnol ; 44(8): 1909-1916, 2016 Dec.
Article en En | MEDLINE | ID: mdl-26631548
Herein, we investigate whether curcumin nanoparticles (Cur NPs) are effective for the treatment of monocrotaline (MCT)-induced pulmonary arterial hypertension in Sprague Dawley rat. Echocardiography was performed at the start of the study and 28 days after MCT injection. Compared to MCT only animals, Cur NP administration was associated with reduced right ventricular (RV) wall thickness and a decreased right ventricle weight/body weight ratio. Cur NPs also attenuated MCT induced increase in RV mRNA expression of TNF-α and IL-1ß. These changes were also associated with decreased RV expression of nitrotyrosine, fibronectin and myosin heavy chain-ß.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Remodelación Ventricular / Curcumina / Nanopartículas / Ventrículos Cardíacos / Hipertensión Pulmonar Límite: Animals Idioma: En Revista: Artif Cells Nanomed Biotechnol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Remodelación Ventricular / Curcumina / Nanopartículas / Ventrículos Cardíacos / Hipertensión Pulmonar Límite: Animals Idioma: En Revista: Artif Cells Nanomed Biotechnol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido