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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects.
Zhang, Hongkai; Sturchler, Emmanuel; Zhu, Jiang; Nieto, Ainhoa; Cistrone, Philip A; Xie, Jia; He, LinLing; Yea, Kyungmoo; Jones, Teresa; Turn, Rachel; Di Stefano, Peter S; Griffin, Patrick R; Dawson, Philip E; McDonald, Patricia H; Lerner, Richard A.
Afiliación
  • Zhang H; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Sturchler E; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA.
  • Zhu J; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Nieto A; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA.
  • Cistrone PA; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Xie J; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
  • He L; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Yea K; Shanghai Institute for Advance Immunological Studies, Shanghai Tech University, Shanghai 200031, China.
  • Jones T; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
  • Turn R; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA.
  • Di Stefano PS; Zebra Biologics Inc., Concord, Massachusetts 01742, USA.
  • Griffin PR; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA.
  • Dawson PE; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.
  • McDonald PH; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA.
  • Lerner RA; Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Nat Commun ; 6: 8918, 2015 Dec 01.
Article en En | MEDLINE | ID: mdl-26621478
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Diabetes Mellitus Tipo 2 / Receptor del Péptido 1 Similar al Glucagón / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Diabetes Mellitus Tipo 2 / Receptor del Péptido 1 Similar al Glucagón / Hipoglucemiantes Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido