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Development of a microscale red blood cell-shaped pectin-oligochitosan hydrogel system using an electrospray-vibration method: preparation and characterization.
Crouse, James Z; Mahuta, Kirsten M; Mikulski, Brandon A; Harvestine, Jenna N; Guo, Xiaoru; Lee, Jung C; Kaltchev, Matey G; Midelfort, Katarina S; Tritt, Charles S; Chen, Junhong; Zhang, Wujie.
Afiliación
  • Crouse JZ; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Mahuta KM; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Mikulski BA; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Harvestine JN; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Guo X; Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI - USA.
  • Lee JC; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Kaltchev MG; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Midelfort KS; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Tritt CS; Biomedical Engineering Program, Department of Electrical Engineering and Computer Science, Milwaukee School of Engineering, Milwaukee, WI - USA.
  • Chen J; Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI - USA.
  • Zhang W; Biomolecular Engineering Program, Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, WI - USA.
J Appl Biomater Funct Mater ; 13(4): e326-31, 2015 Dec 18.
Article en En | MEDLINE | ID: mdl-26616754
PURPOSE: To develop and characterize a microscale pectin-oligochitosan hydrogel microcapsule system that could be applied in such biological fields as drug delivery, cell immobilization/encapsulation, and tissue engineering. METHODS: Microscale pectin-oligochitosan hydrogel microcapsules were prepared by using the vibration/electrostatic spray method. The morphology and chemistry of the hydrogel microcapsules were characterized by using scanning electron microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR), respectively. The designed hydrogel microcapsule system was then used to study the responsiveness of the microcapsules to different simulated human body fluids as well as cell encapsulation. RESULTS: The designed hydrogel microcapsule system exhibited a large surface area-to-volume ratio (red blood cell-shaped) and great pH/enzymatic responsiveness. In addition, this system showed the potential for controlled drug delivery and three-dimensional cell culture. CONCLUSION: This system showed a significant potential not only for bioactive-agent delivery, especially to the lower gastrointestinal (GI) tract, but also as a three-dimensional niche for cell culture. In particular, the hydrogel microcapsule system could be used to create artificial red-blood-cells as well as blood substitutes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogel de Polietilenoglicol-Dimetacrilato Límite: Humans Idioma: En Revista: J Appl Biomater Funct Mater Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogel de Polietilenoglicol-Dimetacrilato Límite: Humans Idioma: En Revista: J Appl Biomater Funct Mater Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos