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DNA Repair Gene Polymorphism and the Risk of Mitral Chordae Tendineae Rupture.
Yigin, Aysel Kalayci; Vatan, Mehmet Bulent; Akdemir, Ramazan; Aksoy, Muhammed Necati Murat; Cakar, Mehmet Akif; Kilic, Harun; Erkorkmaz, Unal; Karacan, Keziban; Kaleli, Suleyman.
Afiliación
  • Yigin AK; Department of Medical Biology and Genetics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Vatan MB; Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Akdemir R; Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Aksoy MN; Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Cakar MA; Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Kilic H; Department of Cardiology, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Erkorkmaz U; Department of Biostatistics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Karacan K; Department of Anatomy, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
  • Kaleli S; Department of Medical Biology and Genetics, Faculty of Medicine, Sakarya University, 54290 Sakarya, Turkey.
Dis Markers ; 2015: 825020, 2015.
Article en En | MEDLINE | ID: mdl-26604426
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis. The aim of the present study was to evaluate the significance of polymorphism Lys939Gln in XPC gene in patients with mitral chordae tendinea rupture (MCTR). Twenty-one patients with MCTR and thirty-seven age and sex matched controls were enrolled in the study. Genotyping of XPC gene Lys939Gln polymorphism was carried out using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP). The frequencies of the heterozygote genotype (Lys/Gln-AC) and homozygote genotype (Gln/Gln-CC) were significantly different in MCTR as compared to control group, respectively (52.4% versus 43.2%, p = 0.049; 38.15% versus 16.2%, p = 0.018). Homozygote variant (Gln/Gln) genotype was significantly associated with increased risk of MCTR (OR = 2.059; 95% CI: 1.097-3.863; p = 0.018). Heterozygote variant (Lys/Gln) genotype was also highly significantly associated with increased risk of MCTR (OR = 1.489; 95% CI: 1.041-2.129; p = 0.049). The variant allele C was found to be significantly associated with MCTR (OR = 1.481; 95% CI: 1.101-1.992; p = 0.011). This study has demonstrated the association of XPC gene Lys939Gln polymorphism with MCTR, which is significantly associated with increased risk of MCTR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerdas Tendinosas / Polimorfismo de Nucleótido Simple / Proteínas de Unión al ADN / Enfermedades de las Válvulas Cardíacas / Válvula Mitral Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerdas Tendinosas / Polimorfismo de Nucleótido Simple / Proteínas de Unión al ADN / Enfermedades de las Válvulas Cardíacas / Válvula Mitral Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos