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No-Reflow Phenomenon in Central Retinal Artery Occlusion: Incidence, Risk Factors, and Clinical Implications.
Ahn, Seong Joon; Park, Kyu Hyung; Ryoo, Na-Kyung; Hong, Jeong-Ho; Jung, Cheolkyu; Yoon, Chang-Hwan; Han, Moon-Ku; Woo, Se Joon.
Afiliación
  • Ahn SJ; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Park KH; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Ryoo NK; Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Hong JH; Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • Jung C; Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Yoon CH; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Han MK; Department of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Woo SJ; Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.
PLoS One ; 10(11): e0142852, 2015.
Article en En | MEDLINE | ID: mdl-26599539
PURPOSE: To investigate the incidence and risk factors of the no-reflow phenomenon in central retinal artery occlusion (CRAO) patients and to determine its effects on visual and anatomic outcomes. METHODS: In 102 eyes with CRAO in which arterial recanalization was obtained within 1 week from baseline, fluorescein angiography images obtained at baseline and 1 week were retrospectively reviewed. The no-reflow phenomenon in the retina was defined as macular capillary nonperfusion following arterial recanalization on fluorescein angiographs. We investigated the incidence and risk factors for the no-reflow phenomenon and compared the anatomical and visual outcomes between eyes with and without the phenomenon. RESULTS: Among the 102 CRAO eyes with arterial recanalization, 39 exhibited the no-reflow phenomenon, resulting in an incidence of 38.2%. The incidence among the eyes with treatment-induced and spontaneous recanalization was 43.4% and 15.8%, respectively, and it increased with the CRAO stage. CRAO stage and increased central macular thickness were risk factors for the phenomenon, with an odds ratio of 4.47 [95% confidence interval (CI), 1.19-16.8; P = 0.027] and 1.69 (95% CI, 1.12-2.55; P = 0.012) per 100-µm increase, respectively. The visual outcome was significantly poorer and retinal atrophy and photoreceptor disruption was greater in eyes with the no-reflow phenomenon than in those without. CONCLUSIONS: The no-reflow phenomenon may occur after arterial recanalization in approximately one-third of CRAO patients and can affect anatomical and visual outcomes. This phenomenon may provide an additional explanation regarding the permanent retinal damage and vision loss in eyes with CRAO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oclusión de la Arteria Retiniana / Fenómeno de no Reflujo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oclusión de la Arteria Retiniana / Fenómeno de no Reflujo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos