Differentiation and Cell-Cell Interactions of Neural Progenitor Cells Transplanted into Intact Adult Brain.
Bull Exp Biol Med
; 160(1): 115-22, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26593411
We studied the behavior and cell-cell interactions of embryonic brain cell from GFP-reporter mice after their transplantation into the intact adult brain. Fragments or cell suspensions of fetal neocortical cells at different stages of development were transplanted into the neocortex and striatum of adult recipients. Even in intact brain, the processes of transplanted neurons formed extensive networks in the striatum and neocortical layers I and V-VI. Processes of transplanted cells at different stages of development attained the rostral areas of the frontal cortex and some of them reached the internal capsule. However, the cells transplanted in suspension had lower process growth potency than cells from tissue fragments. Tyrosine hydroxylase fibers penetrated from the recipient brain into grafts at both early and late stages of development. Our experiments demonstrated the formation of extensive reciprocal networks between the transplanted fetal neural cells and recipient brain neurons even in intact brain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Tejido Encefálico
/
Trasplante de Tejido Fetal
/
Células-Madre Neurales
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2015
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos