[Genome-wide association studies on the developmental dyslexia children].
Wei Sheng Yan Jiu
; 44(5): 767-70, 779, 2015 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-26591772
OBJECTIVE: To find out the potential polymorphisms of gene with developmental dyslexia children. METHODS: From January 2010 to December 2013, 121 cases children with developmental dyslexia and 117 cases health children as the control were enrolled into the study. The potential polymorphisms of gene were found by case-control study strategies based on the Affymetrix Genome-Wide SNP 6. 0 microarray and pathway analysis. RESULTS: Genotypes and allele frequencies of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROBOl gene between cases and control groups were significantly different (P < 0. 05). CONCLUSION: Polymorphism of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROB01 gene may associate with developmental dyslexia children.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Dislexia
/
Estudios de Asociación Genética
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Asunto de la revista:
SAUDE PUBLICA
Año:
2015
Tipo del documento:
Article
Pais de publicación:
China