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Decreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting task.
Ortiz, Nick; Parsons, Aisling; Whelan, Robert; Brennan, Katie; Agan, Maria L F; O'Connell, Redmond; Bramham, Jessica; Garavan, Hugh.
Afiliación
  • Ortiz N; University of Vermont, Department of Psychiatry, Burlington, USA, hugh.garavan@uvm.edu.
  • Parsons A; University College Dublin School of Psychology, Dublin, Ireland.
  • Whelan R; University College Dublin School of Psychology, Dublin, Ireland.
  • Brennan K; University of Vermont, Department of Psychiatry, Burlington, USA.
  • Agan ML; University College Dublin School of Psychology, Dublin, Ireland.
  • O'Connell R; Trinity College Dublin, Trinity College Institute of Neuroscience, Dublin, Ireland.
  • Bramham J; University College Dublin School of Psychology, Dublin, Ireland.
  • Garavan H; University of Vermont, Department of Psychiatry, Burlington, USA.
Acta Neurobiol Exp (Wars) ; 75(3): 326-38, 2015.
Article en En | MEDLINE | ID: mdl-26581388
An important characteristic of childhood attention-deficit/hyperactivity disorder (ADHD) is a bias towards small immediate versus larger delayed rewards, but it is not known if this symptom is also a feature of adult ADHD. A delay-discounting task was administered to participants with adult ADHD and a comparison group in conjunction with functional magnetic resonance imaging. Participants responded to a series of questions that required judgments between small sums of money available immediately and larger sums obtained after a temporal delay. Question parameters were adjusted by an adaptive algorithm designed to converge on each participant's discounting indifference point, an individual set point at which there is equal valuation of both choices. In all participants, robust task activation was observed in regions previously identified in functional imaging studies of delay discounting. However, adults with ADHD showed less task activation in a number of regions including the dorsolateral prefrontal cortex, superior frontal gyrus, anterior cingulate, caudate nucleus and declive of the cerebellum. Additionally, the degree to which a participant discounted delayed rewards was inversely related to task activation in the cerebellum. The results suggest that the bias towards immediate rewards in childhood ADHD may not persist behaviorally, but instead present in adulthood as alterations in frontostriatal and frontocerebellar networks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Cerebelo / Cuerpo Estriado / Descuento por Demora / Lóbulo Frontal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurobiol Exp (Wars) Año: 2015 Tipo del documento: Article Pais de publicación: Polonia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Cerebelo / Cuerpo Estriado / Descuento por Demora / Lóbulo Frontal Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neurobiol Exp (Wars) Año: 2015 Tipo del documento: Article Pais de publicación: Polonia