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Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in Arabidopsis.
Hamdoun, Safae; Zhang, Chong; Gill, Manroop; Kumar, Narender; Churchman, Michelle; Larkin, John C; Kwon, Ashley; Lu, Hua.
Afiliación
  • Hamdoun S; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Zhang C; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Gill M; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Kumar N; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Churchman M; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Larkin JC; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Kwon A; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.).
  • Lu H; Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland 21250 (S.H., C.Z., M.G., A.K., H.L.); andDepartment of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 (N.K., M.C., J.C.L.) hualu@umbc.edu.
Plant Physiol ; 170(1): 515-27, 2016 Jan.
Article en En | MEDLINE | ID: mdl-26561564
Precise cell-cycle control is critical for plant development and responses to pathogen invasion. Two homologous cyclin-dependent kinase inhibitor genes, SIAMESE (SIM) and SIM-RELATED 1 (SMR1), were recently shown to regulate Arabidopsis (Arabidopsis thaliana) defense based on phenotypes conferred by a sim smr1 double mutant. However, whether these two genes play differential roles in cell-cycle and defense control is unknown. In this report, we show that while acting synergistically to promote endoreplication, SIM and SMR1 play different roles in affecting the ploidy of trichome and leaf cells, respectively. In addition, we found that the smr1-1 mutant, but not sim-1, was more susceptible to a virulent Pseudomonas syringae strain, and this susceptibility could be rescued by activating salicylic acid (SA)-mediated defense. Consistent with these results, smr1-1 partially suppressed the dwarfism, high SA levels, and cell death phenotypes in acd6-1, a mutant used to gauge the change of defense levels. Thus, SMR1 functions partly through SA in defense control. The differential roles of SIM and SMR1 are due to differences in temporal and spatial expression of these two genes in Arabidopsis tissues and in response to P. syringae infection. In addition, flow-cytometry analysis of plants with altered SA signaling revealed that SA is necessary, but not sufficient, to change cell-cycle progression. We further found that a mutant with three CYCD3 genes disrupted also compromised disease resistance to P. syringae. Together, this study reveals differential roles of two homologous cyclin-dependent kinase inhibitors in regulating cell-cycle progression and innate immunity in Arabidopsis and provides insights into the importance of cell-cycle control during host-pathogen interactions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Arabidopsis / Proteínas de Ciclo Celular / Proteínas de Arabidopsis / Inmunidad Innata Idioma: En Revista: Plant Physiol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Arabidopsis / Proteínas de Ciclo Celular / Proteínas de Arabidopsis / Inmunidad Innata Idioma: En Revista: Plant Physiol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos