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Prognostic value of p16 expression in Epstein-Barr virus-positive nasopharyngeal carcinomas.
Jiang, Wen; Chamberlain, Paul D; Garden, Adam S; Kim, Betty Y S; Ma, Dominic; Lo, Emily J; Bell, Diana; Gunn, G Brandon; Fuller, Clifton D; Rosenthal, David I; Beadle, Beth M; Frank, Steven J; Morrison, William H; El-Naggar, Adel K; Glisson, Bonnie S; Sturgis, Erich M; Phan, Jack.
Afiliación
  • Jiang W; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Chamberlain PD; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Garden AS; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Kim BY; Department of Cancer Biology, Neurosurgery, Mayo Clinic, Jacksonville, Florida.
  • Ma D; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Lo EJ; Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Bell D; Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Gunn GB; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Fuller CD; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Rosenthal DI; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Beadle BM; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Frank SJ; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Morrison WH; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • El-Naggar AK; Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Glisson BS; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Sturgis EM; Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, Houston, Texas.
  • Phan J; Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas.
Head Neck ; 38 Suppl 1: E1459-66, 2016 04.
Article en En | MEDLINE | ID: mdl-26560893
BACKGROUND: Overexpression of p16 is associated with improved outcomes among patients with oropharyngeal carcinoma. However, its role in the outcomes of patients with nasopharyngeal cancer (NPC) remains unclear. METHODS: Eighty-six patients with NPC treated at MD Anderson Cancer Center from 2000 to 2014 were identified. Epstein-Barr virus (EBV) and human papillomavirus (HPV) status were determined by in situ hybridization (ISH) and p16 by immunohistochemical staining. RESULTS: EBV positivity was associated with extended overall survival (OS; median, 95.0 vs 44.9 months; p < .004), progression-free survival (PFS; median, 80.4 vs 28.1 months; p < .013), and locoregional control (median, 104.4 vs 65.5 months; p < .043). In patients with EBV-positive tumors, p16 overexpression correlated with improved PFS (median, 106.3 vs 27.1 months; p < .02) and locoregional control (median, 93.6 vs 64.5 months; p < .02). CONCLUSION: P16 overexpression is associated with improved PFS and locoregional control in patients with EBV-positive NPC. P16 expression may complement EBV status in predicting treatment outcomes for patients with NPC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1459-E1466, 2016.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Neoplasias Nasofaríngeas / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Infecciones por Virus de Epstein-Barr Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Neoplasias Nasofaríngeas / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Infecciones por Virus de Epstein-Barr Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos