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Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes.
Söder, Stephan; Sesselmann, Stefan; Aigner, Thomas; Oehler, Stephan; Agaimy, Abbas.
Afiliación
  • Söder S; Institute of Pathology, Friedrich-Alexander-University, 91054, Erlangen, Germany.
  • Sesselmann S; Department of Orthopaedic Surgery, Friedrich-Alexander-University, 91054, Erlangen, Germany.
  • Aigner T; Institute of Pathology, Hospital of Coburg, 96450, Coburg, Germany.
  • Oehler S; Department of Orthopaedics, Hospital of Rummelsberg, 90592, Schwarzenbruck, Germany.
  • Agaimy A; Institute of Pathology, Friedrich-Alexander-University, 91054, Erlangen, Germany. abbas.agaimy@uk-erlangen.de.
Virchows Arch ; 468(2): 231-8, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26553457
Tenosynovial giant cell tumour (TSGCT; synonym, pigmented villonodular synovitis (PVNS)) is a rare low-grade mesenchymal neoplasm of either intra-articular or extra-articular origin. The etiopathogenesis of TSGCT is still uncertain, but recent studies showed a translocation involving colony-stimulating factor 1 (CSF-1) gene in a subset of cases. Histological features mimicking TSGCT can sometimes be encountered in periprosthetic interface membranes. To investigate the frequency and morphologic spectrum of this phenomenon, we conducted a systematic analysis of 477 periprosthetic interface membranes and performed immunohistochemical analysis on a subset of lesions compared to genuine TSGCT. In 26 of 477 periprosthetic membrane samples (5 %), at least some TSGCT-like features were found and 18 cases (4 %) strongly resembled it. Wear particles were detected in 100 % of the TSGCT-like lesions but only in 63.3 % of the whole cohort of periprosthetic membranes (p value <0.001). Immunohistochemistry comparing true TSGCT and TSGCT-like membranes showed similar inflammatory infiltrates with slightly elevated CD3+/CD8+ T lymphocytes and a slightly higher proliferation index in TSGCT samples. In conclusion, TSGCT-like changes in periprosthetic membranes likely represent exuberant fibrohistiocytic inflammatory response induced by wear particles and should be distinguished from genuine (neoplastic) TSGCT. Although TSGCT and TSGCT-like periprosthetic membranes represent different entities, their comparable morphology might reflect analogous morphogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinovitis Pigmentada Vellonodular / Linfocitos T / Antígenos CD / Tumores de Células Gigantes Tipo de estudio: Diagnostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinovitis Pigmentada Vellonodular / Linfocitos T / Antígenos CD / Tumores de Células Gigantes Tipo de estudio: Diagnostic_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania