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Krukenberg Tumors of Gastric Origin: The Rationale of Surgical Resection and Perioperative Treatments in a Multicenter Western Experience.
Rosa, Fausto; Marrelli, Daniele; Morgagni, Paolo; Cipollari, Chiara; Vittimberga, Giovanni; Framarini, Massimo; Cozzaglio, Luca; Pedrazzani, Corrado; Berardi, Stefano; Baiocchi, Gian Luca; Roviello, Franco; Portolani, Nazario; de Manzoni, Giovanni; Costamagna, Guido; Doglietto, Giovanni Battista; Pacelli, Fabio.
Afiliación
  • Rosa F; Department of Digestive Surgery, Catholic University of Rome, Rome, Italy. faust.rosa@tiscali.it.
  • Marrelli D; Department of Digestive Surgery, Catholic University - "A. Gemelli" Hospital, Largo A. Gemelli, 8, 00168, Rome, Italy. faust.rosa@tiscali.it.
  • Morgagni P; Institute of Surgical Sciences, University of Siena, Siena, Italy.
  • Cipollari C; Division of Surgery, "G.B. Morgagni, L. Pierantoni" Hospital, Forlì, Italy.
  • Vittimberga G; 1st Division of Surgery, "Borgo Trento" Hospital, University of Verona, Verona, Italy.
  • Framarini M; Division of Surgery, "G.B. Morgagni, L. Pierantoni" Hospital, Forlì, Italy.
  • Cozzaglio L; Department of Surgery and Advanced Cancer Therapies, Morgagni-Pierantoni Hospital, Forlì, Italy.
  • Pedrazzani C; Division of Surgical Oncology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy.
  • Berardi S; General Surgery A, "Borgo Roma" Hospital, University of Verona, Verona, Italy.
  • Baiocchi GL; Surgical Oncology, John Paul II Foundation, Campobasso, Italy.
  • Roviello F; Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.
  • Portolani N; Institute of Surgical Sciences, University of Siena, Siena, Italy.
  • de Manzoni G; Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.
  • Costamagna G; 1st Division of Surgery, "Borgo Trento" Hospital, University of Verona, Verona, Italy.
  • Doglietto GB; Department of Digestive Endoscopy, Catholic University of Rome, Rome, Italy.
  • Pacelli F; Department of Digestive Surgery, Catholic University of Rome, Rome, Italy.
World J Surg ; 40(4): 921-8, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26552908
BACKGROUND: In case of Krukenberg tumor (KT) of gastric origin it is controversial and debated whether radical surgery in case of synchronous KT or metastasectomy in case of metachronous ones is associated with additional benefits. Role of perioperative treatments is unclear. METHODS: Among 2515 female patients who were diagnosed with gastric cancer between January 1990 and December 2012 from 9 Italian centers, 63 presented simultaneously or developed KT as recurrence. RESULTS: Thirty patients presented with synchronous KT, while 33 developed metachronous ovarian metastases during follow-up. The differences between the two groups were analyzed and compared. The median age of 63 patients was 48.0 years (range 31-71). Resection was possible in 53 patients (20 synchronous and 33 metachronous). Twelve patients in the synchronous group and 15 patients of the metachronous group underwent hyperthermic intraperitoneal chemotherapy after resection of KT. All of them underwent adjuvant chemotherapy after KT resection. The median survival for all population was 23 months (95 % confidence interval, 7-39 months). The median survival time in the metachronous group was 36 months, which was significantly longer than that in the synchronous group, 17 months, p < 0.0001. CONCLUSIONS: KT remains a clinical challenge for gastric cancer therapy. The extent of disease and feasibility of removal of the metastatic lesion must be carefully evaluated prior to surgery to define the patients group who could benefit most from a resection associated with perioperative treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Gástricas / Ovariectomía / Tumor de Krukenberg / Procedimientos Quirúrgicos de Citorreducción / Hipertermia Inducida / Recurrencia Local de Neoplasia / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: World J Surg Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Gástricas / Ovariectomía / Tumor de Krukenberg / Procedimientos Quirúrgicos de Citorreducción / Hipertermia Inducida / Recurrencia Local de Neoplasia / Antineoplásicos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Europa Idioma: En Revista: World J Surg Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos