Your browser doesn't support javascript.
loading
Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion.
Kurz, Felix T; Kampf, Thomas; Buschle, Lukas R; Schlemmer, Heinz-Peter; Heiland, Sabine; Bendszus, Martin; Ziener, Christian H.
Afiliación
  • Kurz FT; Department of Neuroradiology, Heidelberg University, Heidelberg, Germany.
  • Kampf T; Department of Radiology, German Cancer Research Center, Heidelberg, Germany.
  • Buschle LR; Department of Experimental Physics 5, Würzburg University, Würzburg, Germany.
  • Schlemmer HP; Department of Radiology, German Cancer Research Center, Heidelberg, Germany.
  • Heiland S; Department of Radiology, German Cancer Research Center, Heidelberg, Germany.
  • Bendszus M; Department of Neuroradiology, Heidelberg University, Heidelberg, Germany.
  • Ziener CH; Department of Neuroradiology, Heidelberg University, Heidelberg, Germany.
PLoS One ; 10(11): e0141894, 2015.
Article en En | MEDLINE | ID: mdl-26544068
Since changes in lung microstructure are important indicators for (early stage) lung pathology, there is a need for quantifiable information of diagnostically challenging cases in a clinical setting, e.g. to evaluate early emphysematous changes in peripheral lung tissue. Considering alveoli as spherical air-spaces surrounded by a thin film of lung tissue allows deriving an expression for Carr-Purcell-Meiboom-Gill transverse relaxation rates R2 with a dependence on inter-echo time, local air-tissue volume fraction, diffusion coefficient and alveolar diameter, within a weak field approximation. The model relaxation rate exhibits the same hyperbolic tangent dependency as seen in the Luz-Meiboom model and limiting cases agree with Brooks et al. and Jensen et al. In addition, the model is tested against experimental data for passively deflated rat lungs: the resulting mean alveolar radius of RA = 31.46 ± 13.15 µm is very close to the literature value (∼34 µm). Also, modeled radii obtained from relaxometer measurements of ageing hydrogel foam (that mimics peripheral lung tissue) are in good agreement with those obtained from µCT images of the same foam (mean relative error: 0.06 ± 0.01). The model's ability to determine the alveolar radius and/or air volume fraction will be useful in quantifying peripheral lung microstructure.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Imagen Molecular Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Imagen Molecular Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos