Your browser doesn't support javascript.
loading
[Serum cystathionine ß-synthase (CBS), cystathionine γ-lyase (CSE ) and cytochrome c oxidase (COX) in copper mine miners potentially expose d to hydrogen sulfide]. / ß-syntaza cystationiny (CBS), γ-liaza cystationiny (CSE) i oksydaza cytochromu c (COX) w surowicy górników kopalni miedzi potencjalnie narazonych na emisje siarkowodoru.
Skoczynska, Anna; Gruszczynski, Leszek; Turczyn, Barbara; Scieszka, Marek; Wojakowska, Anna; Pawlowski, Tomasz; Schmidt, Edward.
Afiliación
  • Skoczynska A; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu / Wroclaw Medical University, Wroclaw, Poland (Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego / Department of Internal and Occupational Diseases and Hypertension). anna.skoczynska@umed.wroc.pl.
  • Gruszczynski L; Miedziowe Centrum Zdrowia / The Copper Health Centre, Lubin, Poland.
  • Turczyn B; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu / Wroclaw Medical University, Wroclaw, Poland (Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego / Department of Internal and Occupational Diseases and Hypertension).
  • Scieszka M; Miedziowe Centrum Zdrowia / The Copper Health Centre, Lubin, Poland.
  • Wojakowska A; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu / Wroclaw Medical University, Wroclaw, Poland (Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego / Department of Internal and Occupational Diseases and Hypertension). anna.wojakowska@umed.wroc.pl.
  • Pawlowski T; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu / Wroclaw Medical University, Wroclaw, Poland (Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego / Department of Internal and Occupational Diseases and Hypertension).
  • Schmidt E; Miedziowe Centrum Zdrowia / The Copper Health Centre, Lubin, Poland.
Med Pr ; 66(4): 539-48, 2015.
Article en Pl | MEDLINE | ID: mdl-26536970
BACKGROUND: The aim of the study was to evaluate serum levels of the target enzyme for H2S toxicity--cytochrome c oxidase (COX) and enzymes involved in the synthesis of H2S--cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) in copper mine miners. MATERIAL AND METHODS: The initial and basic study was conducted respectively in 237 and 88 miners, working in 2 mining shafts: I--no H2S emissions recorded in the last 10 years (study group A) and II--H2S emissions occurred (study group B). A medical examination was performed and 10 ml of blood was collected from miners immediately after exiting the mine. RESULTS: There were no clinical or biochemical changes typical for H2S toxicity. Sulfhemoglobine was undetectable and there were no changes in the red-ox system. However, in group B, regulatory changes were found; a tendency to higher concentration of CBS and CSE, a higher activity of angiotensin converting enzyme (ACE) compared to group A (p<0.05) and a linear relationship between ACE and CSE (r=0.6927; p<0.001). It has been shown that cigarette smoking decreases COX (p<0.05), however, in miners working in shaft II, the decreased level of COX may result also from the presence of H2S in the gaseous emissions. CONCLUSIONS: COX concentration can be a sensitive indicator of exposure to H2S. The measurements of blood H2S concentrations carried out in workplaces should explain the cause of the changes observed in the COX, CBS and CSE activity.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo IV de Transporte de Electrones / Cobre / Cistationina betasintasa / Cistationina gamma-Liasa / Sulfuro de Hidrógeno / Minería / Enfermedades Profesionales Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: Pl Revista: Med Pr Año: 2015 Tipo del documento: Article Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo IV de Transporte de Electrones / Cobre / Cistationina betasintasa / Cistationina gamma-Liasa / Sulfuro de Hidrógeno / Minería / Enfermedades Profesionales Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: Pl Revista: Med Pr Año: 2015 Tipo del documento: Article Pais de publicación: Polonia