Metabolism of cyclobenzaprine in the dog.

Hucker, H B; Balletto, A J; Arison, B H; Zacchei, A G

Hucker, H B; Balletto, A J; Arison, B H; Zacchei, A G.

Drug Metab Dispos ; 6(2): 184-92, 1978.

Article en En | MEDLINE | ID: mdl-26535

RESUMEN

Ten metabolites of cyclobenzaprine, accounting for approximately 50% of the urinary radioactivity, were identified in the urine of dogs to which the labeled drug had been given orally. These included the 1,2-dihydrodiol, three phenolic derivatives, the N-oxide, the 10,11-epoxide, the 10,11-glycol, desmethylcyclobenzaprine, and the glucuronide conjugates of desmethylcyclobenzaprine and cyclobenzaprine. The metabolites were excreted in both the free and conjugated states. Unchanged cyclobenzaprine was present in only minor amounts.

Asunto(s)

Dibenzocicloheptenos/metabolismo; Relajantes Musculares Centrales/metabolismo; Amitriptilina/análogos & derivados; Animales; Biotransformación; Cromatografía de Gases; Cromatografía en Capa Delgada; Dibenzocicloheptenos/orina; Perros; Glucuronatos/metabolismo; Espectroscopía de Resonancia Magnética; Masculino; Espectrometría de Masas; Relajantes Musculares Centrales/orina

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dibenzocicloheptenos / Relajantes Musculares Centrales Límite: Animals Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 1978 Tipo del documento: Article Pais de publicación: Estados Unidos

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