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The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain.
Michels, Kara A; Hartmann, Katherine E; Archer, Kristin R; Ye, Fei; Edwards, Digna R Velez.
Afiliación
  • Michels KA; Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN.
  • Hartmann KE; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD.
  • Archer KR; Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN.
  • Ye F; Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, TN.
  • Edwards DR; Department of Orthopedic Surgery, Vanderbilt University School of Medicine, Nashville, TN.
Paediatr Perinat Epidemiol ; 30(2): 115-23, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26525634
BACKGROUND: Few studies comment on the association between fibroids and symptoms among pregnant women. These studies generally are retrospective and do not to assess the influence of number of tumours or their volume on risk of symptoms. METHODS: Right from the Start is a prospective cohort that enrolled pregnant women from the southeastern USA between 2000 and 2012. In the first trimester, all participants had standardised ultrasounds to determine the presence or absence of fibroids. Symptoms were queried in a telephone survey. We used polytomous logistic regression to model odds of bleeding, pain, or both symptoms in relation to increasing total fibroid number and volume among white and black women. RESULTS: Among 4509 participants, the prevalence of fibroids was 11%. Among those reporting symptoms (70%), 11% reported only bleeding, 59% reported only pain, and 30% reported both symptoms. After adjusting for age, race, parity, hypertension, smoking, alcohol use, and study site, increasing number of fibroids was associated with pain [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.00, 1.33] and both symptoms [OR 1.25, 95% CI 1.08, 1.45] but not with bleeding among all women. Fibroid volume was not associated with symptoms among black women, but white women with the smallest fibroid volumes were more likely to report both symptoms than those without fibroids [OR 1.79, 95% CI 1.17, 2.72]. CONCLUSIONS: Very large tumours are not requisite for experiencing symptoms, as small fibroids and increasing number of tumours are associated with pain and both symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Complicaciones Cardiovasculares del Embarazo / Complicaciones Neoplásicas del Embarazo / Hemorragia Uterina / Neoplasias Uterinas Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Paediatr Perinat Epidemiol Asunto de la revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Complicaciones Cardiovasculares del Embarazo / Complicaciones Neoplásicas del Embarazo / Hemorragia Uterina / Neoplasias Uterinas Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Paediatr Perinat Epidemiol Asunto de la revista: EPIDEMIOLOGIA / PEDIATRIA / PERINATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido