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Epigenomic Regulation of Smad1 Signaling During Cellular Senescence Induced by Ras Activation.
Kaneda, Atsushi; Nonaka, Aya; Fujita, Takanori; Yamanaka, Ryota; Fujimoto, Mai; Miyazono, Kohei; Aburatani, Hiroyuki.
Afiliación
  • Kaneda A; Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. kaneda@genome.rcast.u-tokyo.ac.jp.
  • Nonaka A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan. kaneda@genome.rcast.u-tokyo.ac.jp.
  • Fujita T; CREST, Japan Science and Technology Agency, Saitama, Japan. kaneda@genome.rcast.u-tokyo.ac.jp.
  • Yamanaka R; Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.
  • Fujimoto M; Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.
  • Miyazono K; Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.
  • Aburatani H; Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan.
Methods Mol Biol ; 1344: 341-53, 2016.
Article en En | MEDLINE | ID: mdl-26520136
Epigenomic modification plays important roles in regulating gene expression during development, differentiation, and cellular senescence. When oncogenes are activated, cells fall into stable growth arrest to block cellular proliferation, which is called oncogene-induced senescence. We recently identified through genome-wide analyses that Bmp2-Smad1 signal and its regulation by harmonized epigenomic alteration play an important role in Ras-induced senescence of mouse embryonic fibroblasts. We describe in this chapter the methods for analyses of epigenomic alteration and Smad1 targets on genome-wide scale.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Activación Transcripcional / Regulación de la Expresión Génica / Senescencia Celular / Proteínas ras / Epigénesis Genética / Proteína Smad1 Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Activación Transcripcional / Regulación de la Expresión Génica / Senescencia Celular / Proteínas ras / Epigénesis Genética / Proteína Smad1 Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos