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Targeting post-translational modifications of histones for cancer therapy.
Hsu, Y-C; Hsieh, Y-H; Liao, C-C; Chong, L-W; Lee, C-Y; Yu, Y-L; Chou, R-H.
Afiliación
  • Hsu YC; Mackay Medical College Institute of Biomedical Sciences New Taipei City Taiwan.
  • Hsieh YH; Chung Shan Medical University Department of Biochemistry, School of Medicine Taichung Taiwan.
  • Liao CC; National Yang—Ming University Proteomics Research Center Taipei Taiwan.
  • Chong LW; Shin Kong Wu Ho—Su Memorial Hospital Division of Hepatology and Gastroenterology, Department of Internal Medicine Taipei Taiwan.
  • Lee CY; I—Shou University School of Chinese Medicine for Post—Baccalaureate Kaohsiung Taiwan.
  • Yu YL; China Medical University Graduate Institute of Cancer Biology and Center for Molecular Medicine Taichung Taiwan ylyu@mail.cmu.edu.tw.
  • Chou RH; China Medical University Graduate Institute of Cancer Biology and Center for Molecular Medicine Taichung Taiwan rhchou@mail.cmu.edu.tw.
Cell Mol Biol (Noisy-le-grand) ; 61(6): 69-84, 2015 Oct 30.
Article en En | MEDLINE | ID: mdl-26518898
Post-translational modifications (PTMs) on histones including acetylation, methylation, phosphorylation, citrullination, ubiquitination, ADP ribosylation, and sumoylation, play important roles in different biological events including chromatin dynamics, DNA replication, and transcriptional regulation. Aberrant histones PTMs leads to abnormal gene expression and uncontrolled cell proliferation, followed by development of cancers. Therefore, targeting the enzymes required for specific histone PTMs holds a lot of potential for cancer treatment. In this review article, we retrospect the latest studies in the regulations of acetylation, methylation, and phosphorylation of histones. We also summarize inhibitors/drugs that target these modifications for cancer treatment.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2015 Tipo del documento: Article Pais de publicación: Francia
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2015 Tipo del documento: Article Pais de publicación: Francia