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Effect of omega-3 on hepatic regeneration in adult living donors undergoing hepatic resections for liver transplantation: A randomized controlled trial.
Ibrahim, Eman Sayed; Saleh, Sherif Mohamed; El Hoseeny, Mohamed; El shaarawy, Ahmed.
Afiliación
  • Ibrahim ES; National Liver Institute Menoufia University, Egypt. Electronic address: emansayed825@gmail.com.
  • Saleh SM; National Liver Institute Menoufia University, Egypt.
  • El Hoseeny M; National Liver Institute Menoufia University, Egypt.
  • El shaarawy A; National Liver Institute Menoufia University, Egypt.
J Crit Care ; 31(1): 157-62, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26518479
BACKGROUND: Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been shown to improve liver regeneration in experimental models. Aim was to evaluate the effects of ω-3 PUFAs on hepatic regeneration in adult living donors undergoing partial hepatectomy for liver transplantation (LDLT). METHODS: Forty LDLT donors were categorized into 2 groups: received either intravenous ω-3 PUFA-enriched lipid emulsion 20% infusion 7 mL/kg once a day for 2 days before surgery and postoperative day (POD) 0 (S group) or glucose 5% (C group). Hepatic regeneration was assessed by volume of the liver after 1 month using computed tomography, and serial serum levels of hepatocyte growth factor were measured at POD 1, 3, and 5. RESULTS: Liver volume after 1 month was significantly larger in the S group than the C group (1286.75 ± 122.781 cm(3) vs 1169.15 ± 128.3, respectively; P = .00). Both the regeneration index and the regeneration percentage were significantly higher in the S group than the C group (P = .02 and P = .00, respectively). Serum levels of hepatocyte growth factor were significantly higher in the S group on POD 1, 3, and 5 than the C group ([in pg/mL] 188.10 ± 74.25 vs 123.30 ± 13.56, P = .00; 127.55 ± 32.40 vs 109.25 ± 8.89, P = .02; and 109.45 ± 21.44 vs 96.70 ± 5.57, P = .01; respectively). CONCLUSION: Omega-3 polyunsaturated fatty acids effectively promoted liver regeneration and functional recovery following portal hypertension in the setting of LDLT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Trasplante de Hígado / Donadores Vivos / Hepatectomía / Regeneración Hepática Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Crit Care Asunto de la revista: TERAPIA INTENSIVA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Trasplante de Hígado / Donadores Vivos / Hepatectomía / Regeneración Hepática Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: J Crit Care Asunto de la revista: TERAPIA INTENSIVA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos