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Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis.
Wang, Tiantian; Shan, Ling; Du, Lin; Feng, Junyan; Xu, Zhida; Staal, Wouter G; Jia, Feiyong.
Afiliación
  • Wang T; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
  • Shan L; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
  • Du L; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
  • Feng J; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
  • Xu Z; Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Staal WG; Department of Psychiatry and Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre Karakter, Centre for Child and Adolescent Psychiatry Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.
  • Jia F; Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China. erkekangfujia@163.com.
Eur Child Adolesc Psychiatry ; 25(4): 341-50, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26514973
Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). Vitamin D is regarded as a neuroactive steroid affecting brain development and function. It plays an essential role in myelination, which is important for connectivity in the brain. Studies have shown that decreased vitamin D levels in patients, decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk for ASD. In addition, autism symptoms and global functioning may improve after vitamin D supplementation. Here, we sought to aggregate information from previous publications on vitamin D levels and ASD, in order to achieve a higher statistical power and thereby to determine the validity of vitamin D deficiency as a risk factor for ASD. For this meta-analysis, 11 studies met the inclusion and exclusion criteria, accounting for a total of 870 ASD patients and 782 healthy controls. Levels of serum 25(OH) D in participants with ASD were significantly lower than controls, suggesting that lower vitamin D level might be a risk factor for ASD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Deficiencia de Vitamina D / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina D / Deficiencia de Vitamina D / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: Eur Child Adolesc Psychiatry Asunto de la revista: PEDIATRIA / PSIQUIATRIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania