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Loss of asthma control and activation of coagulation and fibrinolysis.
Sneeboer, M M S; Fens, N; van de Pol, M A; Majoor, C J; Meijers, J C M; Kamphuisen, P W; Lutter, R; Sterk, P J; Bel, E H D.
Afiliación
  • Sneeboer MM; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Fens N; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
  • van de Pol MA; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Majoor CJ; Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Meijers JC; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Kamphuisen PW; Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Lutter R; Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.
  • Sterk PJ; Department of Vascular Medicine, University Medical Center Groningen, The Netherlands.
  • Bel EH; Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
Clin Exp Allergy ; 46(3): 422-7, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26509255
BACKGROUND: Epidemiologic studies have shown that patients with severe asthma have increased risk of pulmonary embolism, in particular patients with frequent asthma exacerbations. Therefore, we hypothesized that asthma exacerbations are associated with increased haemostatic activity. OBJECTIVE: To investigate whether induced loss of asthma control is associated with changes in coagulation and fibrinolytic parameters in peripheral blood. METHODS: We performed a prospective, inhaled steroid withdrawal study in 23 patients with moderate to moderately severe asthma, consisting of a baseline visit and a visit after loss of asthma control. During the visits, we measured asthma control questionnaire (ACQ), atopy, lung function, inflammatory markers (eosinophils and neutrophils), and haemostatic parameters in plasma. RESULTS: Complete cessation of inhaled corticosteroids led to a loss of asthma control in 22 of 23 patients. We found increased asthma symptoms (ACQ 0.9 vs. 2.9, P < 0.01), significantly reduced lung function (forced expiratory volume in 1 s (FEV1) 3.51L vs. 3.13L, P < 0.01) and increased levels of eosinophils in plasma (0.26 × 10(E9)/L vs. 0.16 × 10(E9)/L, P = 0.03) in patients after loss of asthma control. However, we observed no significant changes in the coagulation and fibrinolysis parameters. CONCLUSION: Loss of asthma control after cessation of inhaled corticosteroids does not lead to increased haemostatic activation in patients with moderate to moderately severe asthma. This suggests that more severe inflammation or additional risk factors are required for activation of coagulation or reduction of fibrinolysis in asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Coagulación Sanguínea / Fibrinólisis Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Clin Exp Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Coagulación Sanguínea / Fibrinólisis Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Clin Exp Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido