Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.

Lade, Julie M; To, Elaine E; Hendrix, Craig W; Bumpus, Namandjé N

Lade, Julie M; To, Elaine E; Hendrix, Craig W; Bumpus, Namandjé N.

Afiliación

Lade JM; Department of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophysics 307, Baltimore, MD 21205, USA ; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophy
To EE; Department of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophysics 307, Baltimore, MD 21205, USA ; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophy
Hendrix CW; Department of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 569, Baltimore, MD 21287, USA ; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University School of Medicine, 600 North Wolfe Street, Blalock 5
Bumpus NN; Department of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophysics 307, Baltimore, MD 21205, USA ; Department of Medicine (Division of Clinical Pharmacology), Johns Hopkins University School of Medicine, 725 North Wolfe Street, Biophy

EBioMedicine ; 2(9): 1145-52, 2015 Sep.

Article en En | MEDLINE | ID: mdl-26501112

Asunto(s)

Compartimento Celular; Variación Genética; Proteínas Quinasas/genética; Tenofovir/farmacología; Adulto; Fármacos Anti-VIH/farmacología; Fármacos Anti-VIH/uso terapéutico; Demografía; Etnicidad; Femenino; Técnicas de Silenciamiento del Gen; Infecciones por VIH/tratamiento farmacológico; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Masculino; Persona de Mediana Edad; Mutación Missense/genética; ARN Interferente Pequeño/metabolismo; Tenofovir/uso terapéutico; Adulto Joven

Palabras clave

AK2, adenylate kinase 2; CKM, creatine kinase, muscle; GUK1, guanylate kinase 1; HIV; HIV pre-exposure prophylaxis; HIV, human immunodeficiency virus; MTN-001, Microbicide Trials Network Study MTN-001; Microbicide Trials Network study MTN-001; NME1, NME/NM23 nucleoside diphosphate kinase 1; Nucleotide kinases; PBMC, peripheral blood mononuclear cells; PKLR, pyruvate kinase, liver and red blood cell; PKM, pyruvate kinase, muscle; PrEP, pre-exposure prophylaxis; SNV, single-nucleotide variant; TFV, tenofovir; TFV-DP, tenofovir-diphosphate; TFV-MP, tenofovir-monophosphate; Targeted next-generation sequencing; Tenofovir activation

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Variación Genética / Compartimento Celular / Tenofovir Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google