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The association between the HLA-G 14-bp insertion/deletion polymorphism and type 1 diabetes.
Silva, H P V; Ururahy, M A G; Souza, K S C; Loureiro, M B; Oliveira, Y M C; Oliveira, G H M; Luchessi, A D; Carvalho, K T C; Freitas, J C O C; Donadi, E A; Hirata, R D C; Almeida, M G; Arrais, R F; Hirata, M H; Rezende, A A.
Afiliación
  • Silva HP; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ururahy MA; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Souza KS; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Loureiro MB; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Oliveira YM; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Oliveira GH; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Luchessi AD; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Carvalho KT; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Freitas JC; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Donadi EA; Department of Clinical and Toxicological Analyses, University of Sao Paulo, Sao Paulo, Brazil.
  • Hirata RD; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
  • Almeida MG; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Arrais RF; Pediatrics Endocrinology Unit, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Hirata MH; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
  • Rezende AA; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Genes Immun ; 17(1): 13-8, 2016.
Article en En | MEDLINE | ID: mdl-26492519
Type 1 diabetes (T1D) is a multifactorial disease that has a strong genetic component. The HLA-G is a nonclassical HLA class I locus that is associated with immunomodulatory functions, including downregulation of innate and adaptive immune responses and induction of immune tolerance. However, there is currently limited information about the involvement of HLA-G in T1D susceptibility. This case-control study aims to investigate the T1D susceptibility association of alleles and genotypes of a widely investigated 14-bp insertion/deletion polymorphism in the HLA-G and to provide further evidence of the frequency distribution of class II HLA-DR-DQ-risk genotypes in T1D children and adolescents in the Brazilian population. The deletion allele and the homozygous deletion genotype are associated with susceptibility to T1D and the insertion allele and the heterozygous deletion/insertion genotype are associated with protection from T1D. We also confirm that genetic susceptibility to T1D is associated with the DRB1*03:01-DQA1*05:01-DQB1*02:01 and DRB1*04-DQA1*03:01-DQB1*03:02 haplotypes in Brazilian northeast region. The DR3-DQ2/DR4-DQ8 genotype conferred the highest detected risk for T1D. Our results identify a novel association of the 14-bp deletion allele and the homozygous deletion genotype with T1D development and provide additional evidence of the importance of HLA class II heterozygous DR3-DQ2/DR4-DQ8 genotype in T1D susceptibility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Diabetes Mellitus Tipo 1 / Antígenos HLA-G Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genes Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / Diabetes Mellitus Tipo 1 / Antígenos HLA-G Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: Genes Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido