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Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.
Freschi, Luca; Jeukens, Julie; Kukavica-Ibrulj, Irena; Boyle, Brian; Dupont, Marie-Josée; Laroche, Jérôme; Larose, Stéphane; Maaroufi, Halim; Fothergill, Joanne L; Moore, Matthew; Winsor, Geoffrey L; Aaron, Shawn D; Barbeau, Jean; Bell, Scott C; Burns, Jane L; Camara, Miguel; Cantin, André; Charette, Steve J; Dewar, Ken; Déziel, Éric; Grimwood, Keith; Hancock, Robert E W; Harrison, Joe J; Heeb, Stephan; Jelsbak, Lars; Jia, Baofeng; Kenna, Dervla T; Kidd, Timothy J; Klockgether, Jens; Lam, Joseph S; Lamont, Iain L; Lewenza, Shawn; Loman, Nick; Malouin, François; Manos, Jim; McArthur, Andrew G; McKeown, Josie; Milot, Julie; Naghra, Hardeep; Nguyen, Dao; Pereira, Sheldon K; Perron, Gabriel G; Pirnay, Jean-Paul; Rainey, Paul B; Rousseau, Simon; Santos, Pedro M; Stephenson, Anne; Taylor, Véronique; Turton, Jane F; Waglechner, Nicholas.
Afiliación
  • Freschi L; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Jeukens J; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Kukavica-Ibrulj I; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Boyle B; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Dupont MJ; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Laroche J; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Larose S; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Maaroufi H; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada.
  • Fothergill JL; Institute of Infection and Global Health, University of Liverpool Liverpool, UK.
  • Moore M; Institute of Infection and Global Health, University of Liverpool Liverpool, UK.
  • Winsor GL; Department of Molecular Biology and Biochemistry, Simon Fraser University Vancouver, BC, Canada.
  • Aaron SD; Ottawa Hospital Research Institute Ottawa, ON, Canada.
  • Barbeau J; Faculté de Médecine Dentaire, Université de Montréal Montréal, QC, Canada.
  • Bell SC; QIMR Berghofer Medical Research Institute Brisbane, QLD, Australia.
  • Burns JL; Seattle Children's Research Institute, University of Washington School of Medicine Seattle, WA, USA.
  • Camara M; School of Life Sciences, University of Nottingham Nottingham, UK.
  • Cantin A; Département de Médecine, Université de Sherbrooke Sherbrooke, QC, Canada.
  • Charette SJ; Institute for Integrative and Systems Biology, Université Laval Quebec, QC, Canada ; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec, QC, Canada ; Département de Biochimie, de Microbiologie et de Bio-informatique, Faculté des Sciences et de Génie, Un
  • Dewar K; Department of Human Genetics, McGill University Montreal, QC, Canada.
  • Déziel É; INRS Institut Armand Frappier Laval, QC, Canada.
  • Grimwood K; School of Medicine, Griffith University Gold Coast, QLD, Australia.
  • Hancock RE; Department of Microbiology and Immunology, University of British Columbia Vancouver, BC, Canada.
  • Harrison JJ; Biological Sciences, University of Calgary Calgary, AB, Canada.
  • Heeb S; School of Life Sciences, University of Nottingham Nottingham, UK.
  • Jelsbak L; Department of Systems Biology, Technical University of Denmark Lyngby, Denmark.
  • Jia B; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada.
  • Kenna DT; Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England London, UK.
  • Kidd TJ; Child Health Research Centre, The University of Queensland Brisbane, QLD, Australia ; Centre for Infection and Immunity, Queen's University Belfast Belfast, UK.
  • Klockgether J; Klinische Forschergruppe, Medizinische Hochschule Hannover, Germany.
  • Lam JS; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada.
  • Lamont IL; Department of Biochemistry, University of Otago Dunedin, New Zealand.
  • Lewenza S; Biological Sciences, University of Calgary Calgary, AB, Canada.
  • Loman N; Institute for Microbiology and Infection, University of Birmingham Birmingham, UK.
  • Malouin F; Département de Médecine, Université de Sherbrooke Sherbrooke, QC, Canada.
  • Manos J; Department of Infectious Diseases and Immunology, The University of Sydney Sydney, NSW, Australia.
  • McArthur AG; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada.
  • McKeown J; School of Life Sciences, University of Nottingham Nottingham, UK.
  • Milot J; Department of Pneumology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval Quebec, QC, Canada.
  • Naghra H; School of Life Sciences, University of Nottingham Nottingham, UK.
  • Nguyen D; Department of Human Genetics, McGill University Montreal, QC, Canada ; Department of Microbiology and Immunology and Department of Experimental Medicine, McGill University Montreal, QC, Canada.
  • Pereira SK; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada.
  • Perron GG; Department of Biology, Bard College, Annandale-On-Hudson NY, USA.
  • Pirnay JP; Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital Brussels, Belgium.
  • Rainey PB; New Zealand Institute for Advanced Study, Massey University Albany, New Zealand ; Max Planck Institute for Evolutionary Biology Plön, Germany.
  • Rousseau S; Department of Human Genetics, McGill University Montreal, QC, Canada.
  • Santos PM; Department of Biology, University of Minho Braga, Portugal.
  • Stephenson A; St. Michael's Hospital Toronto, ON, Canada.
  • Taylor V; Department of Molecular and Cellular Biology, University of Guelph Guelph, ON, Canada.
  • Turton JF; Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, Public Health England London, UK.
  • Waglechner N; M.G. DeGroote Institute for Infectious Disease Research, McMaster University Hamilton, ON, Canada.
Front Microbiol ; 6: 1036, 2015.
Article en En | MEDLINE | ID: mdl-26483767
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aeruginosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P. aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Microbiol Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Microbiol Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza