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The hypertriglyceridemic-waist phenotype is associated with the Framingham risk score and subclinical atherosclerosis in Canadian Cree.
Poirier, J; Kubow, S; Noël, M; Dupont, C; Egeland, G M.
Afiliación
  • Poirier J; Center for Indigenous Peoples' Nutrition and Environment (CINE) & School of Dietetics and Human Nutrition, McGill University, 21,111 Lakeshore, St-Anne-de-Bellevue, Québec, H9X 3V9, Canada.
  • Kubow S; Center for Indigenous Peoples' Nutrition and Environment (CINE) & School of Dietetics and Human Nutrition, McGill University, 21,111 Lakeshore, St-Anne-de-Bellevue, Québec, H9X 3V9, Canada.
  • Noël M; University of Ottawa, 25 Université (Room 140), Ottawa, Ontario, K1N 7K4, Canada.
  • Dupont C; Unité de recherche en santé publique, Université Laval, 2875 Boulevard Laurier, Édifice Delta 2, Bureau 600, Québec, Québec G1V 2M2, Canada.
  • Egeland GM; Division of Epidemiology, Norwegian Institute of Public Health & Department of Global Public Health and Primary Care, University of Bergen, Kalfarveien 31, N-5018 Bergen, Norway. Electronic address: g.egeland@igs.uib.no.
Nutr Metab Cardiovasc Dis ; 25(11): 1050-5, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26474723
BACKGROUND AND AIMS: For primary prevention of cardiovascular disease (CVD), Canadian guidelines recommend that asymptomatic Canadians with abdominal obesity undergo Framingham risk score (FRS) assessment, and that in Indigenous Peoples, indicators of metabolic syndrome also be used to identify at-risk individuals. The hypertriglyceridemic-waist phenotype (HTGW) has been proposed to be a surrogate marker of visceral obesity and a simple proxy measure for metabolic syndrome. The primary aim of this study was to evaluate whether the HTGW and the FRS associated with sub-clinical atherosclerosis. METHODS AND RESULTS: Asymptomatic Cree participants in a cross-sectional study conducted 2005-2009 (n = 446, 18-81 y) were assessed for the HTGW using NCEP-ATP-III gender-specific-cutoffs (waist circumference: for men, ≥102 cm; for women ≥88 cm) and fasting triglycerides ≥1.7 mmol/L. Sub-clinical atherosclerosis was defined by the presence of a high sex-specific common-carotid-intimal-medial-wall-thickness (≥75th percentile). HTGW was present in 26.7% and a 10-y FRS greater than 10% was present in 18.8% of participants. The multivariate adjusted OR (95% CI) for sub-clinical atherosclerosis associated with an FRS greater than 10% was 4.10 (2.20-7.50) while that associated with the HTGW phenotype was 1.74 (95% CI 1.61-1.88) from a model including age, body mass index, alcohol consumption, FRS and the HTGW. CONCLUSIONS: The HTGW phenotype is prevalent in the Cree. Our findings support further study on the utility of combining the HTGW with the FRS in the prediction of cardiovascular disease outcomes and in health screening and intervention programs among indigenous peoples.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrigliceridemia / Aterosclerosis / Circunferencia de la Cintura Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 País/Región como asunto: America do norte Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertrigliceridemia / Aterosclerosis / Circunferencia de la Cintura Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged80 País/Región como asunto: America do norte Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos