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Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis.
Chamberlain, Kelly A; Nanescu, Sonia E; Psachoulia, Konstantina; Huang, Jeffrey K.
Afiliación
  • Chamberlain KA; Department of Biology, Georgetown University, Washington, D.C., USA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, D.C., USA.
  • Nanescu SE; Department of Biology, Georgetown University, Washington, D.C., USA.
  • Psachoulia K; Department of Biology, Georgetown University, Washington, D.C., USA.
  • Huang JK; Department of Biology, Georgetown University, Washington, D.C., USA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, D.C., USA. Electronic address: jh1659@georgetown.edu.
Neuropharmacology ; 110(Pt B): 633-643, 2016 Nov.
Article en En | MEDLINE | ID: mdl-26474658
Oligodendrocytes readily regenerate and replace myelin membranes around axons in the adult mammalian central nervous system (CNS) following injury. The ability to regenerate oligodendrocytes depends on the availability of neural progenitors called oligodendrocyte precursor cells (OPCs) in the adult CNS that respond to injury-associated signals to induce OPC expansion followed by oligodendrocyte differentiation, axonal contact and myelin regeneration (remyelination). Remyelination ensures the maintenance of axonal conduction, and the oligodendrocytes themselves provide metabolic factors that are necessary to maintain neuronal integrity. Recent advances in oligodendrocyte regeneration research are beginning to shed light on critical intrinsic signals, as well as extrinsic, environmental factors that regulate the distinct steps of oligodendrocyte lineage progression and myelin replacement under CNS injury. These studies may offer novel pharmacological targets for regenerative medicine in inflammatory demyelinating disorders in the CNS such as multiple sclerosis. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Neuroprotección / Esclerosis Múltiple / Vaina de Mielina / Regeneración Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Neuropharmacology Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Neuroprotección / Esclerosis Múltiple / Vaina de Mielina / Regeneración Nerviosa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Neuropharmacology Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido