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Delayed and Aberrant Presentation of VX2 Carcinoma in a Rabbit Model of Hepatic Neoplasia.
Hansen, Sarah A; Fink, Michael K; Upendran, Anandhi; Besch-Williford, Cynthia L; Livingston, Robert S; Amos-Landgraf, James M; Lattimer, Jimmy C; Kannan, Raghuraman.
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  • Hansen SA; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA. hansensa@missouri.edu.
  • Fink MK; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
  • Upendran A; Department of Institute of Clinical and Translational Sciences, University of Missouri, Columbia, Missouri, USA.
  • Besch-Williford CL; Department of IDEXX BioResources, Columbia, Missouri, USA.
  • Livingston RS; Department of IDEXX BioResources, Columbia, Missouri, USA.
  • Amos-Landgraf JM; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
  • Lattimer JC; Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA.
  • Kannan R; Department of Radiology and Bio-Engineering, University of Missouri, Columbia, Missouri, USA.
Comp Med ; 65(5): 424-8, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26473347
A socially-housed New Zealand white rabbit presented with a large subcutaneous mass on the ventral thorax approximately 11 mo after the intrahepatic delivery of a suspension of VX2 carcinoma cells to induce hepatocellular carcinoma as part of a nanoparticle study. The mass and closely associated axillary lymph node were removed en bloc. Immunohistochemical staining identified the mass as an undifferentiated carcinoma. The rabbit demonstrated no appreciable pathology at the study end point at 16 mo after VX2 inoculation. An additional rabbit from the same VX2 injection cohort was found at necropsy to have an unanticipated intraabdominal mass, also identified as an undifferentiated carcinoma. This case report summarizes the molecular analysis of both tumors through a novel PCR assay, which identified the delayed and aberrant onset of VX2 carcinoma in an extended timeframe not previously reported.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Torácicas / Carcinoma Hepatocelular / Neoplasias Abdominales / Neoplasias Hepáticas Experimentales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Comp Med Asunto de la revista: MEDICINA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Torácicas / Carcinoma Hepatocelular / Neoplasias Abdominales / Neoplasias Hepáticas Experimentales Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Comp Med Asunto de la revista: MEDICINA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos