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Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis.
Yiu, Kai Hang; Ninaber, Maarten K; Kroft, Lucia J; Schouffoer, Anne A; Stolk, Jan; Scherer, Hans U; Meijs, Jessica; de Vries-Bouwstra, Jeska; Tse, Hung Fat; Delgado, Victoria; Bax, Jeroen J; Huizinga, Tom W J; Marsan, Nina Ajmone.
Afiliación
  • Yiu KH; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Interuniversity Cardiology Institute of the Netherlands, Utrecht.
  • Ninaber MK; Department of Pulmonology.
  • Kroft LJ; Department of Radiology.
  • Schouffoer AA; Department of Rheumatology, Leiden University Medical Center, Leiden and Department of Rheumatology, Haga Teaching Hospital, The Hague, The Netherlands.
  • Stolk J; Department of Pulmonology.
  • Scherer HU; Department of Rheumatology, Leiden University Medical Center, Leiden and.
  • Meijs J; Department of Rheumatology, Leiden University Medical Center, Leiden and.
  • de Vries-Bouwstra J; Department of Rheumatology, Leiden University Medical Center, Leiden and.
  • Tse HF; Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
  • Delgado V; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bax JJ; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Huizinga TW; Department of Rheumatology, Leiden University Medical Center, Leiden and.
  • Marsan NA; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, n.ajmone@lumc.nl.
Rheumatology (Oxford) ; 55(3): 504-12, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26472568
OBJECTIVES: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function. METHODS: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function. RESULTS: A total of 51 (50%) SSc patients did not have pulmonary fibrosis or PHT, 32 (31%) patients had pulmonary fibrosis but no PHT and the remaining 19 (19%) patients had both pulmonary fibrosis and PHT. Patients with both pulmonary fibrosis and PHT had the most impaired RV free wall strain [-16.8% (s.d. 3.1)] compared with patients with pulmonary fibrosis and no PHT [-21.5% (s.d. 3.6)] and patients with no pulmonary fibrosis and no PHT [-24.0% (s.d. 4.4)]. All three SSc groups showed impaired RV free wall strain compared with controls [-28.0% (s.d. 4.2)]. Importantly, multivariate regression analysis demonstrated that pulmonary fibrosis and left ventricular ejection fraction were independently associated with impaired RV free wall strain in SSc patients. CONCLUSION: SSc patients show impaired RV function compared with controls. Both pulmonary fibrosis and PHT are independently associated with RV dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Esclerodermia Sistémica / Interpretación de Imagen Asistida por Computador / Disfunción Ventricular Derecha / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Esclerodermia Sistémica / Interpretación de Imagen Asistida por Computador / Disfunción Ventricular Derecha / Hipertensión Pulmonar Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido