The Protective Effects of Epigallocatechin Gallate Against Distant Organ Damage After Severe Skin Burns--Experimental Study Using a Rat Model of Thermal Trauma.
Adv Clin Exp Med
; 24(3): 409-17, 2015.
Article
en En
| MEDLINE
| ID: mdl-26467128
BACKGROUND: Epigallocatechin gallate (EGCG), a green tea polyphenol, has potent antioxidant properties. OBJECTIVES: The purpose of the present study was to examine the possible preventative effects of EGCG against internal organ injury due to large-surface skin burns in a rat model. MATERIAL AND METHODS: The study design involved three groups of rats: a sham group and two groups with 25-30% full-thickness burns: (a) the sham group without burns or treatment (n=18); (b) the control burn group (burns+sterile saline, n=18); and (c) the burn treatment group (burns+treatment with EGCG, n=18). EGCG was administered intraperitoneally immediately after the thermal injury, and daily in 100 µmol/kg doses. Kidney and lung tissue samples were taken to determine the levels of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), and glutathione peroxidase (GPX) after the first, third and seventh post-burn days. RESULTS: In the EGCG-treated burn group, SOD and GPX activity were significantly higher than in the burn control group. Additionally, MDA and TNF-α levels were significantly lower in the EGCG-treated burn group. CONCLUSIONS: Based on this study, it might be anticipated that EGCG treatment may be beneficial in burn injury cases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Quemaduras
/
Catequina
/
Sustancias Protectoras
/
Lesión Pulmonar
/
Enfermedades Renales
/
Antioxidantes
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Adv Clin Exp Med
Año:
2015
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Polonia