Your browser doesn't support javascript.
loading
Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.
Zinzow-Kramer, W M; Horton, B M; McKee, C D; Michaud, J M; Tharp, G K; Thomas, J W; Tuttle, E M; Yi, S; Maney, D L.
Afiliación
  • Zinzow-Kramer WM; Department of Psychology, Emory University, Atlanta, GA.
  • Horton BM; Department of Psychology, Emory University, Atlanta, GA.
  • McKee CD; Department of Psychology, Emory University, Atlanta, GA.
  • Michaud JM; Department of Psychology, Emory University, Atlanta, GA.
  • Tharp GK; Yerkes Nonhuman Primate Genomics Core, Emory University, Atlanta, GA.
  • Thomas JW; NIH Intramural Sequencing Center, National Human Genome Research Institute, NIH, Rockville, MD.
  • Tuttle EM; Department of Biology, Indiana State University, Terre Haute, IN.
  • Yi S; The Center for Genomic Advocacy, Indiana State University, Terre Haute, IN.
  • Maney DL; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Genes Brain Behav ; 14(8): 641-54, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26463687
The genome of the white-throated sparrow (Zonotrichia albicollis) contains an inversion polymorphism on chromosome 2 that is linked to predictable variation in a suite of phenotypic traits including plumage color, aggression and parental behavior. Differences in gene expression between the two color morphs, which represent the two common inversion genotypes (ZAL2/ZAL2 and ZAL2/ZAL2(m) ), may therefore advance our understanding of the molecular underpinnings of these phenotypes. To identify genes that are differentially expressed between the two morphs and correlated with behavior, we quantified gene expression and terrirorial aggression, including song, in a population of free-living white-throated sparrows. We analyzed gene expression in two brain regions, the medial amygdala (MeA) and hypothalamus. Both regions are part of a 'social behavior network', which is rich in steroid hormone receptors and previously linked with territorial behavior. Using weighted gene co-expression network analyses, we identified modules of genes that were correlated with both morph and singing behavior. The majority of these genes were located within the inversion, showing the profound effect of the inversion on the expression of genes captured by the rearrangement. These modules were enriched with genes related to retinoic acid signaling and basic cellular functioning. In the MeA, the most prominent pathways were those related to steroid hormone receptor activity. Within these pathways, the only gene encoding such a receptor was ESR1 (estrogen receptor 1), a gene previously shown to predict song rate in this species. The set of candidate genes we identified may mediate the effects of a chromosomal inversion on territorial behavior.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Sexual Animal / Vocalización Animal / Gorriones / Inversión Cromosómica Límite: Animals Idioma: En Revista: Genes Brain Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / GENETICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Sexual Animal / Vocalización Animal / Gorriones / Inversión Cromosómica Límite: Animals Idioma: En Revista: Genes Brain Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / GENETICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido