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FLAIR2: A Combination of FLAIR and T2 for Improved MS Lesion Detection.
Wiggermann, V; Hernández-Torres, E; Traboulsee, A; Li, D K B; Rauscher, A.
Afiliación
  • Wiggermann V; From the Departments of Physics and Astronomy (V.W.) Pediatrics (V.W., E.H.T., A.R.) University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.).
  • Hernández-Torres E; Pediatrics (V.W., E.H.T., A.R.) University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.).
  • Traboulsee A; Medicine (Neurology) (A.T., D.K.B.L.).
  • Li DK; Medicine (Neurology) (A.T., D.K.B.L.) Radiology (D.K.B.L.) Centre for Brain Health (D.K.B.L., A.R.).
  • Rauscher A; Pediatrics (V.W., E.H.T., A.R.) University of British Columbia MRI Research Centre (V.W., E.H.T., A.R.) Centre for Brain Health (D.K.B.L., A.R.) Child and Family Research Institute (A.R.), University of British Columbia, Vancouver, British Columbia, Canada. rauscher@physics.ubc.ca.
AJNR Am J Neuroradiol ; 37(2): 259-65, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26450539
BACKGROUND AND PURPOSE: FLAIR and double inversion recovery are important MR imaging scans for MS. The suppression of signal from CSF in FLAIR and the additional suppression of WM signal in double inversion recovery improve contrast between lesions, WM and GM, albeit at a reduced SNR. However, whether the acquisition of double inversion recovery is necessary is still debated. Here, we present an approach that allows obtaining CSF-suppressed images with improved contrast between lesions, WM and GM without strongly penalizing SNR. MATERIALS AND METHODS: 3D T2-weighted and 3D-FLAIR data acquired from September 2014 to April 2015 in healthy volunteers (23.4 ± 2.4 years of age; female/male ratio, 3:2) and patients (44.1 ± 14.0 years of age; female/male ratio, 4:5) with MS were coregistered and multiplied (FLAIR(2)). SNR and contrast-to-noise measurements were performed for focal lesions and GM and WM. Furthermore, data from 24 subjects with relapsing-remitting and progressive MS were analyzed retrospectively (52.7 ± 8.1 years of age; female/male ratio, 14:10). RESULTS: The GM-WM contrast-to-noise ratio was by 133% higher in FLAIR(2) than in FLAIR and improved between lesions and WM by 31%, 93%, and 158% compared with T2, DIR, and FLAIR, respectively. Cortical and juxtacortical lesions were more conspicuous in FLAIR(2). Furthermore, the 3D nature of FLAIR(2) allowed reliable visualization of callosal and infratentorial lesions. CONCLUSIONS: We present a simple approach for obtaining CSF suppression with an improved contrast-to-noise ratio compared with conventional FLAIR and double inversion recovery without the acquisition of additional data. FLAIR(2) can be computed retrospectively if T2 and FLAIR scans are available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Interpretación de Imagen Asistida por Computador / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: AJNR Am J Neuroradiol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Interpretación de Imagen Asistida por Computador / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: AJNR Am J Neuroradiol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos