Enhanced acid protease activity of lysosomes from papillary thyroid carcinoma.
Cancer
; 63(6): 1179-82, 1989 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-2645038
In vitro lysosomal acid protease activity was studied in human papillary thyroid carcinoma (n = 13). As a control, morphologically normal thyroid tissue from the same patient was used in each individual case of carcinoma. Although a marked variation may be observed between individual cases, each examined papillary thyroid carcinoma showed significantly greater activity of acid proteases, both per unit weight of wet thyroid tissue and per unit of lysosomal proteins, in comparison to the corresponding control (range, 24%-248%). In conclusion, it is suggested that enhanced proteolytic activity of lysosomal acid proteases in papillary carcinoma is probably a result of disturbance in catabolic degradation of the thyroglobulin molecule in malignantly transformed thyroid tissue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptido Hidrolasas
/
Neoplasias de la Tiroides
/
Carcinoma Papilar
/
Lisosomas
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cancer
Año:
1989
Tipo del documento:
Article
País de afiliación:
Yugoslavia
Pais de publicación:
Estados Unidos