A review of the biology and toxicologic implications of the induction of lysosomal lamellar bodies by drugs.
Toxicol Appl Pharmacol
; 97(1): 47-56, 1989 Jan.
Article
en En
| MEDLINE
| ID: mdl-2644721
Over 30 drugs of differing pharmacologic action are capable of inducing lamellar bodies of lysosomal origin in cells of animals and humans. The structures develop because of a drug-induced impairment in lysosomal phospholipid catabolism. Toxicity frequently accompanies the induction of these bodies. However, little information exists as to whether their development or presence is causally linked to the cellular or tissue dysfunction. This review examines the biological aspects of the induction of lysosomal lamellar bodies by drugs and considers the toxicologic implications of their presence in cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxicología
/
Lisosomas
/
Lípidos de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Toxicol Appl Pharmacol
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Estados Unidos