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Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.
Ben-Gedalya, Tziona; Moll, Lorna; Bejerano-Sagie, Michal; Frere, Samuel; Cabral, Wayne A; Friedmann-Morvinski, Dinorah; Slutsky, Inna; Burstyn-Cohen, Tal; Marini, Joan C; Cohen, Ehud.
Afiliación
  • Ben-Gedalya T; Biochemistry and Molecular Biology, The Institute for Medical Research Israel - Canada (IMRIC), The Hebrew University Medical School, Jerusalem, Israel.
  • Moll L; Biochemistry and Molecular Biology, The Institute for Medical Research Israel - Canada (IMRIC), The Hebrew University Medical School, Jerusalem, Israel.
  • Bejerano-Sagie M; Biochemistry and Molecular Biology, The Institute for Medical Research Israel - Canada (IMRIC), The Hebrew University Medical School, Jerusalem, Israel.
  • Frere S; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Cabral WA; Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, MD, USA.
  • Friedmann-Morvinski D; Biochemistry and Molecular Biology, Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.
  • Slutsky I; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Burstyn-Cohen T; Institute for Dental Sciences, Faculty of Dental Medicine Hebrew University - Hadassah, Jerusalem, Israel.
  • Marini JC; Bone and Extracellular Matrix Branch, NICHD, NIH, Bethesda, MD, USA.
  • Cohen E; Biochemistry and Molecular Biology, The Institute for Medical Research Israel - Canada (IMRIC), The Hebrew University Medical School, Jerusalem, Israel ehudc@ekmd.huji.ac.il.
EMBO J ; 34(22): 2820-39, 2015 Nov 12.
Article en En | MEDLINE | ID: mdl-26438723
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Sustitución de Aminoácidos / Presenilina-1 / Enfermedad de Alzheimer / Agregación Patológica de Proteínas Límite: Animals Idioma: En Revista: EMBO J Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Sustitución de Aminoácidos / Presenilina-1 / Enfermedad de Alzheimer / Agregación Patológica de Proteínas Límite: Animals Idioma: En Revista: EMBO J Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido