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Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Wang, Songyan; Li, Bing; Li, Chunguang; Cui, Wenpeng; Miao, Lining.
Afiliación
  • Wang S; Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China ; Department of Nephrology, Jilin Province People's Hospital, Changchun 130021, China.
  • Li B; Department of Nephrology, Jilin Province People's Hospital, Changchun 130021, China.
  • Li C; Department of Urology, The 2nd Hospital of Changchun, Changchun 130061, China.
  • Cui W; Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China.
  • Miao L; Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China.
J Diabetes Res ; 2015: 962383, 2015.
Article en En | MEDLINE | ID: mdl-26421309
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. In this review, we only focus on the potential renoprotective therapeutic agents which can specifically abolish CCN2 expression or nonspecifically inhibit CCN2 expression for retarding the development and progression of DN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Nefropatías Diabéticas / Factor de Crecimiento del Tejido Conjuntivo / Riñón Límite: Animals / Humans Idioma: En Revista: J Diabetes Res Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Nefropatías Diabéticas / Factor de Crecimiento del Tejido Conjuntivo / Riñón Límite: Animals / Humans Idioma: En Revista: J Diabetes Res Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido