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Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial.
Andrade, Suellen Marinho; Fernández-Calvo, Bernardino; Boggio, Paulo Sérgio; de Oliveira, Eliane Araújo; Gomes, Lilze Franklim; Pinheiro Júnior, José Eudes Gomes; Rodrigues, Rafaela Martins; de Almeida, Natália Leandro; Moreira, Gioconda Marla de Siqueira; Alves, Nelson Torro.
Afiliación
  • Andrade SM; Cognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. suellenandrade@gmail.com.
  • Fernández-Calvo B; Cognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. bfcalvo@usal.es.
  • Boggio PS; Cognitive Neuroscience Laboratory and Developmental Disorders Program, Mackenzie Presbyterian University, São Paulo, SP, Brazil. psboggio@gmail.com.
  • de Oliveira EA; Center for Research in Human Movement Sciences, Federal University of Paraíba, João Pessoa, PB, Brazil. elianeao@gmail.com.
  • Gomes LF; Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. lilzeffg@yahoo.com.br.
  • Pinheiro Júnior JE; Department of Sciences of Religions, NOUS Group, Federal University of Paraíbas, João Pessoa, PB, Brazil. juninho_eudes@hotmail.com.
  • Rodrigues RM; Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. rafaela.estagiaria@hotmail.com.
  • de Almeida NL; Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. natalialalmeida@hotmail.com.
  • Moreira GM; Perception, Neurosciences and Behavior Laboratory, Federal University of Paraíba, João Pessoa, PB, Brazil. giocondasiqueira@gmail.com.
  • Alves NT; Cognitive Neuroscience and Behavior Program, Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil. nelsontorro@yahoo.com.br.
Trials ; 16: 435, 2015 Sep 29.
Article en En | MEDLINE | ID: mdl-26420269
BACKGROUND: Stroke patients may present severe cognitive impairments, primarily related to executive functions. Transcranial direct current stimulation has shown promising results, with neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. METHODS/DESIGN: Sixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session. Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study. DISCUSSION: Long-term stimulation could be analyzed in regard to possible adaptive changes on plasticity after structural brain damage and if these changes are different in terms of clinical improvement when applied to two important cognitive centers. TRIALS REGISTRATION: Clinicaltrials.gov, NCT02315807 . 9 December 2014.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Cognición / Trastornos del Conocimiento / Estimulación Transcraneal de Corriente Directa / Rehabilitación de Accidente Cerebrovascular Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Cognición / Trastornos del Conocimiento / Estimulación Transcraneal de Corriente Directa / Rehabilitación de Accidente Cerebrovascular Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido