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Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors.
Gaffney, P M; Witte, C; Clifford, D L; Imai, D M; O'Brien, T D; Trejo, M; Liberta, F; Annamalai, K; Fändrich, M; Masliah, E; Munson, L; Sigurdson, C J.
Afiliación
  • Gaffney PM; Departments of Pathology and Medicine, University of California-San Diego, La Jolla, CA, USA Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA.
  • Witte C; Wildlife Disease Laboratories, Institute for Conservation Research, San Diego Zoo Global, Escondido, CA, USA.
  • Clifford DL; Wildlife Investigations Laboratory, California Department of Fish and Wildlife, Rancho Cordova, CA, USA Department of Veterinary Medicine and Epidemiology, University of California-Davis, Davis, CA, USA.
  • Imai DM; Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA.
  • O'Brien TD; Veterinary Population Medicine Department, Veterinary Diagnostic Laboratory, University of Minnesota, St Paul, MN, USA.
  • Trejo M; Departments of Pathology and Neuroscience, University of California-San Diego, La Jolla, CA, USA.
  • Liberta F; Institute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
  • Annamalai K; Institute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
  • Fändrich M; Institute for Pharmaceutical Biotechnology, Ulm University, Helmholtzstrasse, Ulm, Germany.
  • Masliah E; Departments of Pathology and Neuroscience, University of California-San Diego, La Jolla, CA, USA.
  • Munson L; Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA Deceased Supplemental material for this article is available on the Veterinary Pathology website at http://vet.sagepub.com/supplemental.
  • Sigurdson CJ; Departments of Pathology and Medicine, University of California-San Diego, La Jolla, CA, USA Department of Pathology, Immunology, and Microbiology, University of California-Davis, Davis, CA, USA csigurdson@ucsd.edu.
Vet Pathol ; 53(3): 637-47, 2016 May.
Article en En | MEDLINE | ID: mdl-26419399
Systemic amyloid A (AA) amyloidosis is highly prevalent (34%) in endangered island foxes (Urocyon littoralis) and poses a risk to species recovery. Although elevated serum AA (SAA) from prolonged or recurrent inflammation predisposes to AA amyloidosis, additional risk factors are poorly understood. Here we define the severity of glomerular and medullary renal amyloid and identify risk factors for AA amyloidosis in 321 island foxes necropsied from 1987 through 2010. In affected kidneys, amyloid more commonly accumulated in the medullary interstitium than in the glomeruli (98% [n= 78 of 80] vs 56% [n= 45], respectively;P< .0001), and medullary deposition was more commonly severe (19% [n= 20 of 105]) as compared with glomeruli (7% [n= 7];P= .01). Univariate odds ratios (ORs) of severe renal AA amyloidosis were greater for short- and long-term captive foxes as compared with free-ranging foxes (ORs = 3.2, 3.7, respectively; overall P= .05) and for females as compared with males (OR = 2.9;P= .05). Multivariable logistic regression revealed that independent risk factors for amyloid development were increasing age class (OR = 3.8;P< .0001), San Clemente Island subspecies versus San Nicolas Island subspecies (OR = 5.3;P= .0003), captivity (OR = 5.1;P= .0001), and nephritis (OR = 2.3;P= .01). The increased risk associated with the San Clemente subspecies or captivity suggests roles for genetic as well as exogenous risk factors in the development of AA amyloidosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Amiloide A Sérica / Zorros / Amiloidosis / Nefritis Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Pathol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Amiloide A Sérica / Zorros / Amiloidosis / Nefritis Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Vet Pathol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos