A rapid HPLC method for plasma and serum mexiletine determination and its use in therapeutic drug monitoring.
Pol J Pharmacol Pharm
; 41(5): 459-67, 1989.
Article
en En
| MEDLINE
| ID: mdl-2641399
A HPLC method for the determination of mexiletine in human plasma and serum is described. Serum or plasma after addition of mexiletine and internal standard was extracted with diisopropyl ether. The extract was then evaporated and dissolved in the mobile phase. An aliquot of the solution was chromatographed on a reversed-phase C8 column. The peaks were detected by UV (214 nm) at room temperature. The limit of detection of mexiletine was approximately 0.02 mg/l of plasma or serum. The validity of the method is discussed and compared with other methods.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Mexiletine
Límite:
Humans
Idioma:
En
Revista:
Pol J Pharmacol Pharm
Año:
1989
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Polonia